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B-Complex and B-12

product on market Tablet or Pill Puritan's Pride Premium Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 80% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

B-complex vitamins and B12 support cellular energy metabolism and neurological function, with strong evidence supporting their role in deficiency prevention. Protease is an enzyme that aids protein digestion, though evidence for its general supplemental benefit is more limited. The ingredient profile maintains a high safety rating.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for B-Complex and B-12
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
180
Servings
Other Combinations
Product Type
80%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

2.5 mg (167% DV)
2.1× RDA — within safe limits 76 studies (A:0, B:33)
2.5 mg (147% DV)
1.9× RDA — within safe limits 13 studies (A:0, B:1)
5 mg (25% DV)
Within RDA (0.4× RDA) 196 studies (A:5, B:63)
100 mcg (1667% DV)
41.7× RDA — above typical dose 139 studies (A:1, B:44)
Protease
10 mg

Other Ingredients

Cellulose Dicalcium Phosphate Silica Magnesium Stearate Stearic Acid
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Directions: For adults, take one (1) tablet one to two times daily, preferably with meals.

Warnings & Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Formulation Notes

No artificial color or flavor, no preservatives, no sugar, no milk, no lactose, no soy, no gluten, no wheat, no yeast, no fish. Sodium free.

Vegetarian Vitamin Supplement

Additional Information

Shop online www.puritan.com

B

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QA Quality Assured

Metadata

Product Details

UPC / SKU0 25077 00194 1
DSLD Entry Date2023-05-24
Product TypeOther Combinations
FormTablet or Pill
BrandPuritan's Pride Premium
DSLD ID284977
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
View all evidence for Thiamine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.