🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
60 Servings
Non-Nutrient/Non-Botanical Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

200 mg
📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)
This product: 200mg

Other Ingredients

Microcrystalline Cellulose Stearic Acid Glycerol Sodium Alginate Colloidal Silica Anhydrous Arginine Magnesium Stearate Magnesium Stearate Colloidal Silica Anhydrous

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Usage (for adults only): Take on an empty stomach during the day. For mood balance: 1-4 tablets 2 times per day or as directed by a health professional. For joint support: 1-3 tablets 2 times per day or as directed by a health professional. Do not exceed a total of 8 tablets per day. For best results, take SAMe for a minimum of 2 weeks, at which time effects should be observed.

⚠️ Warnings & Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding or trying to conceive, or if you are taking medication, have a medical condition or anticipate a surgery.

Individuals with bipolar disorder or depression, anxiety disorders, or taking antidepressant medication should consult their health professional prior to use.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

🧪 Formulation Notes

SAMe supports mood and has a positive effect on emotional well-being. It also maintains joint health. Natural Factors SAMe is released slowly.

Manufactured to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Contains no artificial colors, preservatives or sweeteners; no dairy, wheat, gluten, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs.

Suitable for vegetarians/vegans.

PRODUCT OF U.S.A.

Mood & joint support

Additional Information

ISURA NON-GMO MASS SPEC Documentation Lab Tested

For freshness, store in a cool, dry place. For optimum freshness, refrigerate after opening.

Recyclable container and label.

Product Details

UPC / SKU 0 68958 02708 1
DSLD Entry Date 2023-01-23
Product Type Non-Nutrient/Non-Botanical
Form Tablet or Pill
DSLD ID 282629
Data Updated 2026-04-11

Research Evidence

12 Research Sources
58 Avg Quality Score
8 Meta Analysis
3 Systematic Review
1 Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024
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