🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

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Label Data

2 Vegetarian Capsule(s) Serving Size
45 Servings
Non-Nutrient/Non-Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 1000mg

Other Ingredients

Hypromellose Water

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (82% of products) Nutrient (8% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Kosher Gluten Free

Product Information

📋 Directions for Use

Suggested Use: Take 2 capsules, 1 to 3 times daily, as needed, preferably with meals.

⚠️ Warnings & Precautions

Warning: Not intended for use by persons under the age of 18. Keep out of reach of children.

If you are pregnant, breast feeding, have known medical conditions. (including kidney or liver disease) or are taking prescription or OTC medication(s) consult with your health care practitioner before using this product.

Discontinue use two weeks prior to surgery.

WARNING: Consuming this product can expose you to chemicals including lead, which are known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov/food.

🧪 Formulation Notes

Vegetarian

Gluten free Non-GMO Lactose free

OU (Kosher)

Additional Information

Check. Verify. Trust. View Independent Lab Results CHECKMYSUPPS.COM

Manufactured in our GMP & FDA inspected facility FDA Registration: 16906175560 Made in USA -with ingredients- sourced worldwide

OU (Kosher)

Store in a cool dry place.

Product Details

UPC / SKU 6 49908 52197 4
DSLD Entry Date 2022-12-13
Product Type Non-Nutrient/Non-Botanical
Form Capsule
Brand NutraBio
DSLD ID 278721
Data Updated 2026-04-11

Research Evidence

23 Research Sources
47 Avg Quality Score
18 Rct
3 Systematic Review
1 Meta Analysis
1 Clinical Trial
B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
Rct Nutrients 2016
C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
Rct Hepatology (Baltimore, Md.) 2009
C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
Systematic Review Journal of inherited metabolic disease 2017
C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines
Systematic Review Journal of inherited metabolic disease 2015
C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
Rct European journal of nutrition 2023
C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis
Meta Analysis International orthodontics 2019
C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct The American journal of clinical nutrition
C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
Rct Clinical nutrition ESPEN
C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct The American journal of clinical nutrition
C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine
Rct Cardiovascular drugs and therapy 2009
View all evidence for Betaine →

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