🟢 95/100

This product looks safe

  • Folate: 833mg is 833.0× the Tolerable Upper Intake Level (1.0mg)
  • 86% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

This formula combines B vitamins, zinc, and amino acid precursors like 5-HTP and DL-Phenylalanine to support neurotransmitter synthesis. Research provides moderate to strong evidence for these ingredients in maintaining cognitive function and mood regulation. The overall profile maintains a high safety score, though individual tolerance to amino acids may vary.

AI-generated summary based on research evidence. Not medical advice.

Product Label

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Safety Alerts

⚠️ Folate: 833mg is 833.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

2 Capsule(s) Serving Size
60 Servings
Other Combinations Product Type
86% Evidence Coverage

Supplement Facts — Evidence Check

6.7 mg (394% DV)
📊 5.2× RDA — above typical dose (UL: 100 mg) 📚 114 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 6.7mg UL 100mg
833 mcg DFE (208% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 833.0× (UL: 1.0 mg) 📚 226 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 833mg UL 1.0mg
10 mg (91% DV)
✅ Within RDA (0.9× RDA of 11 mg) 📚 263 studies (Tier A: 6, B: 134)
RDA 11mg This product: 10mg UL 40mg
DL-Phenylalanine
700 mg
100 mg
📊 Market median: 100.0mg (116 products) 📚 18 studies (Tier A: 0, B: 3)
This product: 100mg
📊 Market median: 450.0mg (254 products) 📚 243 studies (Tier A: 0, B: 100)
This product: 250mg
100 mg
📊 Market median: 500.0mg (283 products) 📚 174 studies (Tier A: 0, B: 62)
This product: 100mg

Other Ingredients

Cellulose Water

Label Claims — Verification

All Other
Structure/Function
All Other (98% of products) Structure/Function (89% of products) Nutrient (43% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free

Product Information

📋 Directions for Use

Recommendations: As a dietary supplement, take 2 capsules, 1-2 times daily, between meals.

⚠️ Warnings & Precautions

Warning: Not to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, particularly psychiatric medications, consult your health professional before use. Do not use concurrently with antidepressants.

Phenylketonurics: Contains Phenylalanine.

Keep out of the reach of children.

Use only if safety seal is intact.

🧪 Formulation Notes

PureSYNAPSE product line; Supports emotional, neurocognitive and behavioral health

Gluten-free, Non-GMO & Hypoallergenic

Gluten-free, Non-GMO & Hypoallergenic

Additional Information

Store in a cool, dry place.

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

GFCO.org Certified Gluten-Free by the Gluten-Free Certification Organization, www.gluten.org

Scan to learn about our hypoallergenic supplements

Product Details

UPC / SKU 7 66298 01456 2
DSLD Entry Date 2022-11-22
Product Type Other Combinations
Form Capsule
DSLD ID 277955
Data Updated 2026-04-11

Research Evidence

153 Research Sources
55 Avg Quality Score
71 Systematic Review
51 Meta Analysis
19 Rct
6 Clinical Trial
2 Other
2 Regulatory Source
1 Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022
View all evidence for Vitamin B6 →

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DSLD ID: 277955 Fetched: 2026-04-11
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