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Digest-Plex

product on market Capsule Patient One 1 MediNutritionals Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for Digest-Plex
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Non-Nutrient/Non-Botanical
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

500 mg
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
Papain
50 mg
25 mg
Market median: 200.0mg (136 products) 3 studies — no high-quality reviews
Pepsin
40 mg

Other Ingredients

Vegetable Cellulose Leucine Rice Flour
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: Take 1 capsule at the beginning of each meal as a dietary supplement or as directed by your health professional. May take up to 6 capsules daily as needed.

Warnings & Precautions

Caution: Discontinue use immediately if a burning sensation occurs. Not recommended for people with ulcers or a history of ulcers.

If you are pregnant, nursing, or taking any medications, consult your health practitioner before use.

Discontinue use and consult your health practitioner if any adverse reactions occur.

Keep out of reach of children.

Use only if safety seal is intact.

Formulation Notes

Vegetarian

Gluten free Non GMO Free of: Milk, egg, fish, peanuts, crustacean shellfish, soy, tree nuts, wheat, yeast and gluten. Free of ingredients derived from GMOs.

Betaine HCL plus Pepsin, Papain and Bromelain

Additional Information

Store in a cool, dry place.

BPA free

Exclusive professional formulas

Metadata

Product Details

UPC / SKU8 53959 00478 6
DSLD Entry Date2022-10-24
Product TypeNon-Nutrient/Non-Botanical
FormCapsule
BrandPatient One 1 MediNutritionals
DSLD ID276252
Data Updated2026-04-11
Research

Research Evidence

23
Research Sources
47
Avg Quality
18
Rct
3
Systematic Review
1
Meta Analysis
1
Clinical Trial
B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
Rct Nutrients 2016 PubMed DOI
C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
Rct Hepatology (Baltimore, Md.) 2009 PubMed DOI
C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
Systematic Review Journal of inherited metabolic disease 2017 PubMed DOI
C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines
Systematic Review Journal of inherited metabolic disease 2015 PubMed DOI
C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
Rct European journal of nutrition 2023 PubMed DOI
C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis
Meta Analysis International orthodontics 2019 PubMed DOI
C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct The American journal of clinical nutrition PubMed DOI
C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
Rct Clinical nutrition ESPEN PubMed DOI
C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct The American journal of clinical nutrition PubMed DOI
C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine
Rct Cardiovascular drugs and therapy 2009 PubMed DOI
View all evidence for Betaine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.