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SAMe 400 mg

product on market Tablet or Pill Source Naturals Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

SAMe is used to support mood and joint health, with moderate evidence suggesting efficacy in managing depressive symptoms. Research indicates it may act as a methyl donor in various biochemical reactions. The evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAMe 400 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
30
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

400 mg
Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Cellulose Methacrylic Acid Copolymer Mannitol Citric Acid Stearic Acid Silica Hydroxypropyl Methylcellulose Triacetin Sodium Starch Glycolate modified Cellulose Gum
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: 1 tablet 1 to 3 times daily. Take tablets on an empty stomach.

Warnings & Precautions

Warning: If you are pregnant, may become pregnant, breastfeeding or are taking antidepressant medication, consult your physician before using this product.

Use this product under medical supervision if you have bipolar disorder. In a small number of people this product may cause nausea or gastrointestinal upset. If you experience discomfort, discontinue use.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Formulation Notes

S-adenosyl-L-methionine 400 mg

Improved enteric coating Supports joint comfort, function and mobility

Source Naturals SAMe is a stable, bio-available form of S-adenosyl-L-methionine. These tablets are enteric coated and blister packed for consistent quality and optimal bioactivity. SAMe is present in every living cell in the body and plays an important part in many critical cellular functions. A number of clinical studies have demonstrated that SAMe supplementation supports joint comfort, function and mobility in the spine, hips and knees. Preliminary research suggests that SAMe may work by supporting the production of proteoglycans, which are important components of cartilage. Numerous clinical studies have also demonstrated that SAMe can help support a positive outlook. It is able to cross the blood-brain barrier, where it is thought to affect the synthesis of neurotransmitters, and to help maintain normal membrane fluidity. SAMe works together with the B-vitamins, in particular folic acid, making it important to obtain adequate amounts of the B-vitamin complex from diet and supplements. SAMe plays a key role in transmethylation, a vital type of chemical reaction that affects the synthesis, activation, and metabolism of various biological molecules. Compounds that require this reaction include phospholipids, which are fundamental for all cell membrane functions and for cell to cell communication.

Suitable for vegetarians.

Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no sugar, preservatives, or artificial color, flavor or fragrance.

Metadata

Product Details

DSLD Entry Date2022-10-24
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
DSLD ID275626
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.