🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

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Label Data

1 Tablet(s) Serving Size
60 Servings
Non-Nutrient/Non-Botanical Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

200 mg
📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)
This product: 200mg

Other Ingredients

Dicalcium Phosphate Riboflavin Microcrystalline Cellulose Croscarmellose Sodium Stearic Acid Magnesium Stearate Silicon Dioxide HPMC Titanium Dioxide

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Sugar Free

Product Information

📋 Directions for Use

Suggested Use: As a dietary supplement, take one (1) tablet one to two times daily, preferably on empty stomach, or as directed by your qualified healthcare professional.

⚠️ Warnings & Precautions

Caution: For adults only, if you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of the reach of children.

Do not use if safety seal is broken or missing.

🧪 Formulation Notes

SAMe (S-adenosyl methionine), a compound native to the body, is a critical component of many biochemical reactions, including those that affect brain biochemistry and joint health. SAMe is critical for the synthesis of neurotransmitters, is important for energy production in the brain, contributes to the maintenance of healthy cell membrane function, and influences cartilage metabolism. Best Naturals SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation.

(S-Adenosyl L-Methionine)

Premium formula

3rd party lab tested Enteric coated

No artificial color, flavor or sweetener, no preservatives, no sugar, no starch, no corn, no soy, no egg, no lactose, no gluten, no wheat, no yeast, no fish.

Additional Information

Keep in cool, dry place.

Made in USA

GMP Good Manufacturing Practice Product

Product Details

UPC / SKU 8 17716 01144 8
DSLD Entry Date 2022-06-16
Product Type Non-Nutrient/Non-Botanical
Form Tablet or Pill
DSLD ID 270057
Data Updated 2026-04-11

Research Evidence

12 Research Sources
58 Avg Quality Score
8 Meta Analysis
3 Systematic Review
1 Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024
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