🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
28 Servings
Other Combinations Product Type
50% Evidence Coverage

Supplement Facts — Evidence Check

Calories
Total Carbohydrates
1 Gram(s) (1% DV)
Vitamin C
90 mg (100% DV)
3 mg (27% DV)
✅ Within RDA (0.3× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 3mg UL 40mg
📊 Market median: 80.0mg (20 products) 📚 334 studies (Tier A: 8, B: 183)
This product: 53mg
📊 Market median: 175.0mg (497 products) 📚 11 studies (Tier A: 0, B: 1)
This product: 100mg

Other Ingredients

Mannitol Xylitol Hydroxypropyl Cellulose Stearic Acid Natural Flavors Magnesium Stearate Stevia leaf extract Vegetable Juice

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (54% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Once daily

Directions: Take one (1) tablet daily. Tablet may be chewed or swallowed as desired. Continued use is suggested.

⚠️ Warnings & Precautions

Tamper Evident: Product is sealed within a vial. Do not use if any part of the vial is torn, open or damaged. When first taking Culturelle, you may experience minor bloating, gas or intestinal gurgling which should subside with continued use. Consult your healthcare professional if symptoms persist after two weeks. For questions, concerns or to report an adverse event, please call (800) 722-3476.

Keep out of reach of children.

Inform a healthcare professional before starting any dietary supplement, particularly if there is a known immune-compromised condition.

🧪 Formulation Notes

Culturelle Immune Defense leverages a powerful blend containing clinically studied probiotics, along with naturally-sourced elderberry, plus vitamin C & zinc. It helps keep you feeling your best all year long. LGG Probiotic LGG strain is the most clinically studied probiotic & helps protect your immune health by working in your body’s digestive system where 70% of your immune system is located. Elderberry, Vitamin C & Zinc Made with real elderberry fruit, these chewables taste great and deliver zinc and the antioxidant vitamin C to help support your immune system.

Culturelle probiotics are great for a healthy microbiome & a healthy microbiome is great for a healthy you. Bilayer tablet

Not a reduced calorie food.

Naturally sourced LGG strain

Most clinically researched strain in the world Based on the number of scientific and clinical studies of Lactobacillus rhamnosus GG for a range of benefits as of January 2020. Guaranteed purity & potency Guaranteed potency through date on box when stored as directed.

Dairy Gluten While this product contains an ingredient sourced from wheat, it meets the FDA's definition of gluten free (less than 20 ppm gluten). Soy Free

Probiotics Super immunity chewables

Probiotic + Elderberry, Vitamin C & Zinc

Helps keep your immune system going strong Helps to keep you healthy

Great mixed berry flavor with other natural flavors

Allergy Friendly

Free from Tree nuts Peanuts Milk Eggs

Additional Information

Storage Instructions: Store Culturelle in a cool, dry place away from direct sunlight.

Scan to learn more

Our brand values We’re on a mission to inspire better health & wellness for you & your family. We believe in integrity, so we hold ourselves to the highest standards of truth. We believe in the natural power of your body’s microbiome, & in scientific research & products that will unlock its full potential. We believe in uncompromising quality, safety & proven efficacy. We believe in empowering you to embrace every day with confidence.

The Culturelle difference Excludes gummy formulas. From the Most Trusted Probiotic Brand Based on the 2019 BrandSpark American Shopper Study.

Product Details

UPC / SKU 0 49100 40122 5
DSLD Entry Date 2022-06-16
Product Type Other Combinations
Form Tablet or Pill
Brand Culturelle
DSLD ID 268506
Data Updated 2026-04-11

Research Evidence

371 Research Sources
54 Avg Quality Score
148 Meta Analysis
82 Systematic Review
71 Rct
62 Clinical Trial
2 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Other
1 Openfda Safety
A Vitamin C supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin C supplementation for the primary prevention of cardiovascular disease
Systematic Review The Cochrane database of systematic reviews 2017
A Vitamin C for preventing and treating the common cold
Meta Analysis The Cochrane database of systematic reviews 2013
A Vitamin C for preventing and treating pneumonia
Meta Analysis The Cochrane database of systematic reviews 2013
A Vitamin E supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2015
A Vitamin C supplementation for prevention and treatment of pneumonia
Meta Analysis The Cochrane database of systematic reviews 2020
A Vitamin C supplementation for prevention and treatment of pneumonia
Systematic Review The Cochrane database of systematic reviews 2021
A Nutritional interventions for preventing and treating pressure ulcers
Meta Analysis The Cochrane database of systematic reviews 2024
A Does Vitamin C Supplementation Provide a Protective Effect in Periodontal Health? A Systematic Review and Meta-Analysis
Meta Analysis International journal of molecular sciences 2024
A Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Meta Analysis BMC medicine 2021
View all evidence for Vitamin C →

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