SAMe 400 mg by Swanson — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Tablet(s) Serving Size

30 Servings

Non-Nutrient/Non-Botanical Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

SAMe

400 mg

📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)

This product: 400mg

Other Ingredients

Microcrystalline Cellulose Stearic Acid Magnesium Stearate Magnesium Oxide Silica Calcium Oxide Magnesium Silicate Shellac Glycerol Arginine Sodium Alginate

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Suggested Use: As a dietary supplement, take one tablet one to four times per day with water.

⚠️ Warnings & Precautions

Warning: For adults only.

Consult your healthcare provider before use if you are pregnant or nursing, taking antidepressant medication or if you have bipolar disorder.

Keep out of reach of children.

Do not use if seal is broken.

🧪 Formulation Notes

Enteric coated to enhance stability.

Promotes emotional wellness, healthy mood and neurotransmitter production Supports healthy joint function Precursor to glutathione, a cellular antioxidant believed to be a "master nutrient" for longevity

Emotional Wellness and Joint Health High Potency

400 mg per tablet

Additional Information

Store in a cool, dry place.

swanson.com or call 1-800-437-4148

Science-Backed Quality Since 1969

Product Details

UPC / SKU 0 87614 02218 5

DSLD Entry Date 2022-06-16

Product Type Non-Nutrient/Non-Botanical

Form Tablet or Pill

Brand Swanson

DSLD ID 266878

Data Updated 2026-04-11

Research Evidence

12 Research Sources

58 Avg Quality Score

8 Meta Analysis

3 Systematic Review

1 Rct

B S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2006

PubMed

B S-adenosyl methionine (SAMe) for depression in adults

Meta Analysis The Cochrane database of systematic reviews 2016

PubMed

B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease

Meta Analysis Annals of the rheumatic diseases 2024

PubMed DOI

B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis

Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024

PubMed DOI

B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis

Meta Analysis General hospital psychiatry 2024

PubMed DOI

B S-adenosyl-L-methionine for alcoholic liver diseases

Systematic Review The Cochrane database of systematic reviews 2001

PubMed

B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis