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St. John's Wort

product on market Capsule DC Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 33% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

St. John's Wort, Valerian root, and Passion Flower are researched for their potential to support mood and sleep. There is moderate evidence suggesting these ingredients may help manage mild depressive symptoms and anxiety. However, overall evidence coverage for this specific combination remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for St. John's Wort
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
60
Servings
Botanical
Product Type
33%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 300.0mg (240 products) 20 studies — no high-quality reviews
Market median: 300.0mg (214 products) 25 studies (A:0, B:6)
Passion Flower concentrate
15 mg

Other Ingredients

Vegetable Cellulose Gelatin Silica Vegetable Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 1 to 2 capsules one to three times daily.

Warnings & Precautions

Tamper Evident: Do not use if printed seal under cap is broken or missing. Warning: Use sunscreen during exposure to the sun while using this product.

If you are pregnant, nursing or taking any prescription medication do not take this product.

Keep out of reach of children.

Formulation Notes

St. John's Wort is very popular in Europe where is is favored for its ability to support a balanced state of personal well being. This assured potency formulation is made from the same type of St. John's Wort extract used in major research studies. Our extract contains 0.3% hypericin, the same level of this important constituent used in clinical trials. Concentrated, standardized extracts of Valerian root and Passion Flower herb are added to the standardized St. John's Wort extract to optimize the natural benefits of this exceptional dietary supplement. This balanced approach to formulation of dietary supplements ensures all naturally occurring constituents are available.

FDA Registered Facility (Reg. 1023013) Mfg. under Good Manufacturing Practices (GMPs).

Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.

Gluten free

Standardized assured potency 0.3% Hypericin

The "mood herb" Supports a balanced state of personal well being

Made in USA

Additional Information

Keep tightly closed. Store at room temperature: 59 degrees-86 degrees F (15 degrees to 30 degrees C).

Quali Pure

Metadata

Product Details

DSLD Entry Date2022-02-23
Product TypeBotanical
FormCapsule
BrandDC
DSLD ID266609
Data Updated2026-04-11
Research

Research Evidence

43
Research Sources
48
Avg Quality
16
Meta Analysis
14
Systematic Review
7
Rct
4
Regulatory Source
1
Clinical Trial
1
Openfda Safety
B St John's wort for major depression
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
B Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis
Meta Analysis Journal of affective disorders 2017 PubMed DOI
B A systematic review of St. John's wort for major depressive disorder
Meta Analysis Systematic reviews 2016 PubMed DOI
B St John's wort for depression
Systematic Review The Cochrane database of systematic reviews 2000 PubMed
B Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Meta Analysis Neuropsychopharmacology reports 2025 PubMed DOI
B St John's wort for depression
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
C St John's wort for depression: meta-analysis of randomised controlled trials
Meta Analysis The British journal of psychiatry : the journal of mental science 2005 PubMed
C The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Rct Complementary therapies in medicine 2019 PubMed DOI
C Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks
Rct BMJ (Clinical research ed.) 1999 PubMed
C Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis
Meta Analysis Scientific reports 2016 PubMed DOI
View all evidence for St Johns Wort →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.