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The Original SAMe 200 mg

product on market Tablet or Pill Nutralife Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for The Original SAMe 200 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Tablet(s)
Serving Size
30
Servings
Non-Nutrient/Non-Botanical
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 500.0mg (193 products) 7 studies — no high-quality reviews

Other Ingredients

S-Adenosyl-Methionine Tosylate Disulfate Cellulose Mannitol Citric Acid Stearic Acid Silica Sodium Starch Glycolate Modified Cellulose Gum Methacrylic Acid Copolymer Hydroxypropyl Methylcellulose Triacetin Titanium Dioxide yellow Ochre
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: Clinical studies show that supplementation of 400 mg (or two tablets) a day is effective for most people. Different levels of supplementation may be beneficial to some people.

Warnings & Precautions

Caution: Do not use if blister foil is punctured or appears in any way to have been tampered with.

Keep out of reach of children.

If you are currently taking prescription anti-depressants, consult your physician before using SAMe. If you are pregnant or lactating, consult your physician before taking this product.

If you suffer from bipolar (manic) depression, do not use this product.

Formulation Notes

200 mg active S-Adenosyl-Methionine per tablet

Clinically shown to maintain: Mood & emotional well being Healthy liver function Joint health and comfort Joint mobility

SAMe is found in every living being. It is an important physiological agent synthesized by the body, and it is involved in over 40 biochemical reactions, some of which affect: Mood SAMe and Emotional Well-Being: SAMe is essential to the manufacture of many important brain compounds such as neurotransmitters and phospholipids, which are critical for maintaining healthy mood and emotional well-being. Joints SAMe and Joint Mobility: Clinical studies indicate that SAMe may play an important role in the manufacture of cartilage and that SAMe helps produce proteoglycans, essential components in healthy joint function and mobility. Liver SAMe and Liver Function: SAMe is involved in many processes of the liver. SAMe is essential to maintaining glutathione levels, which is critical for proper liver function. As people age, SAMe levels can decrease. SAMe supplementation may be an important factor in maintaining mobility, and a healthy body and mind. NutraLife SAMe: NutraLife SAMe is the same form that has been available in Europe for over two decades. NutraLife offers the only form of SAMe with 20 years of historical data for both effectiveness and safety. NutraLife SAMe is manufactured and packaged with the highest quality and safety standards. Each NutraLife SAMe tablet contains 200 mg of active S-Adenosyl-Methionine and is manufactured in full accordance with GMP. NutraLife SAMe is the original SAMe brand introduced to the United States almost two decades ago. NutraLife SAMe continues to be made with the highest quality active S,S isomer SAMe raw material.

NutraLife SAMe is kosher certified by Star-K and contains no animal byproducts.

NutraLife SAMe is kosher certified by Star-K and contains no animal byproducts. NutraLife SAMe does not contain talc.

NutraLife SAMe tablets are manufactured in a carefully controlled environment and are cold form blister packaged to ensure a more than two year stability rating.

NutraLife SAMe enteric coated tablets are Kosher certified by: Star-K (Kosher)

This product contains no peanuts, eggs, dairy, soy, wheat, yeast, gluten, tree nuts, crustacean shellfish, fish or other animal byproducts.

Each NutraLife SAMe tablet contains 400 mg SAMe tosylate disulfate, which includes 200 mg of the active ingredient SAMe (S-Adenosyl-Methionine)

NutraLife SAMe tablets are sealed in blister packs to ensure product safety, quality and freshness.

Additional Information

Manufactured in Accordance with GMP

This product should be stored in a dry, cool place.

Star-K (Kosher)

Metadata

Product Details

DSLD Entry Date2022-09-22
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
DSLD ID264358
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.