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5-HTP Plus

product on market Tablet or Pill Natrol Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 83% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

L-5-Hydroxytryptophan is supported by moderate evidence for mood regulation, while B6 and B12 facilitate neurotransmitter synthesis. Magnesium and calcium contribute to neurological function and muscle relaxation. Research for these combined ingredients is generally well-established, though the specific formulation's synergy has limited clinical data.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP Plus
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Other Combinations
Product Type
83%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1.7 mg (100% DV)
1.3× RDA — within safe limits 114 studies (A:3, B:35)
2.4 mcg (100% DV)
Within RDA (1.0× RDA) 139 studies (A:1, B:44)
Calcium
31 mg (2% DV)
5 mg (2% DV)
Market median: 500.0mg (1 products) 316 studies (A:8, B:159)
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)
500 mcg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)

Other Ingredients

Methylcellulose Microcystalline Cellulose Hypromellose Stearic Acid Silicon Dioxide Magnesium Stearate Glycerin Acacia Gum
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 1 tablet, two times daily with food. Do not exceed recommended dose.

Warnings & Precautions

Warning: Consult you healthcare professional prior to use if you have or suspect a medical condition or are taking prescription drugs, including drugs for depression, migraines, Parkinson's disease or psychiatric disorders. Do not use with other supplements containing L-Tryptophan or 5-HTP. Do not use if you are pregnant, lactating or under the age of 18 years.

Do not use if you are pregnant, lactating or under the age of 18 years.

Keep out of reach of children.

Formulation Notes

Natrol 5-HTP Plus Promotes a calm, relaxed mood an helps maintain a positive outlook Enables production of Serotonin 100% Drug Free & non-habit forming Time release formula helps you stay relaxed throughout the day.

Mood & Relaxation Time Release

Promotes a calm & relaxed mood throughout the day

100% drug free

Extra Strength

Vegetarian

No: Milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans, yeast, artificial colors or flavors, added sugar or preservatives.

Additional Information

Store in a cool dry place.

Metadata

Product Details

UPC / SKU0 47469 07360 2
DSLD Entry Date2021-10-22
Product TypeOther Combinations
FormTablet or Pill
BrandNatrol
DSLD ID260264
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.