5-HTP Plus

product on market Tablet or Pill Natrol 🟢 Safety: 100/100
Brand: Natrol
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 83% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
Other Combinations Product Type
83% Evidence Coverage

Supplement Facts — Evidence Check

1.7 mg (100% DV)
✅ 1.3× RDA — within safe limits 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 1.7mg UL 100mg
2.4 mcg (100% DV)
✅ Within RDA (1.0× RDA of 0.0024 mg) 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.0024mg
Calcium
31 mg (2% DV)
5 mg (2% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 5mg
100 mg
📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 100mg
500 mcg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 0.5mg

Other Ingredients

Methylcellulose Microcystalline Cellulose Hypromellose Stearic Acid Silicon Dioxide Magnesium Stearate Glycerin Acacia Gum

Label Claims — Verification

❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (78% of products) Nutrient (52% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Women (not pregnant or lactating) Dairy Free

Product Information

📋 Directions for Use

Directions: Take 1 tablet, two times daily with food. Do not exceed recommended dose.

⚠️ Warnings & Precautions

Warning: Consult you healthcare professional prior to use if you have or suspect a medical condition or are taking prescription drugs, including drugs for depression, migraines, Parkinson's disease or psychiatric disorders. Do not use with other supplements containing L-Tryptophan or 5-HTP. Do not use if you are pregnant, lactating or under the age of 18 years.

Do not use if you are pregnant, lactating or under the age of 18 years.

Keep out of reach of children.

🧪 Formulation Notes

Natrol 5-HTP Plus Promotes a calm, relaxed mood an helps maintain a positive outlook Enables production of Serotonin 100% Drug Free & non-habit forming Time release formula helps you stay relaxed throughout the day.

Mood & Relaxation Time Release

Promotes a calm & relaxed mood throughout the day

100% drug free

Extra Strength

Vegetarian

No: Milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans, yeast, artificial colors or flavors, added sugar or preservatives.

Additional Information

Store in a cool dry place.

Product Details

UPC / SKU 0 47469 07360 2
DSLD Entry Date 2021-10-22
Product Type Other Combinations
Form Tablet or Pill
Brand Natrol
DSLD ID 260264
Data Updated 2026-04-11

Research Evidence

21 Research Sources
53 Avg Quality Score
11 Systematic Review
6 Rct
4 Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018
PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001
PubMed Cochrane
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002
PubMed Cochrane
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024
PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025
PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023
PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025
PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010
PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020
PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025
PubMed DOI
View all evidence for 5 Htp →

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