Methyl Combo by Nature's Sunshine — Ingredients, Evidence & Safety

🟢 80/100

This product is generally safe

Folate: 1333mg is 1333.0× the Tolerable Upper Intake Level (1.0mg)
100% of ingredients have research evidence

C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 1333mg is 1333.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 VegCap(s) Serving Size

60 Servings

Vitamin Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Folate

1333 mcg DFE (333% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 1333.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 1333mg UL 1.0mg

Vitamin B12

1000 mcg (41667% DV)

📊 416.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 1.0mg

Other Ingredients

Cellulose Dicalcium Phosphate Vegetable Capsule Magnesium Stearate Silicon Dioxide

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Recommended Use: Take 1 vegcap twice daily, or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Warnings: Consult your medical provider before use if you have any medical conditions or concerns. Do not use if inner seal is missing or damaged.

🧪 Formulation Notes

Contributes to a reduction of tiredness and fatigue.

Methyl Combo is a powerful blend of Methyl B12 and Methyl Folate that was designed using the most biologically active forms of these key nutrients. These essential vitamins support the nervous system, and overall well-being.

Nervous system support

Methyl B12 & Methyl Folate combination

Guaranteed pure

Additional Information

Bottle made from 100% post consumer recycled material. We are committed to you and our planet. Scan to learn more.

New look! Same great product

Herbal experts since 1972

Product Details

UPC / SKU 0 99904 21689 1

DSLD Entry Date 2021-09-24

Product Type Vitamin

Form Capsule

Brand Nature's Sunshine

DSLD ID 255371

Data Updated 2026-04-11

Research Evidence

363 Research Sources

57 Avg Quality Score

187 Meta Analysis

56 Systematic Review

54 Rct

29 Guideline

26 Clinical Trial

6 Cochrane Review

2 Regulatory Source

1 Other

1 Openfda Safety

A Homocysteine-lowering interventions for preventing cardiovascular events

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI

A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies

Meta Analysis Digestive diseases and sciences 2021

PubMed DOI

A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis

Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021

PubMed DOI

A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta Analysis Nutrients 2024

PubMed DOI

A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis

Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025

PubMed DOI

A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies

Meta Analysis Critical reviews in food science and nutrition 2019

PubMed DOI

A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials

Meta Analysis Critical reviews in food science and nutrition 2022

PubMed DOI

A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants

Meta Analysis Critical reviews in food science and nutrition 2023

PubMed DOI

A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care

Meta Analysis The Cochrane database of systematic reviews 2025

PubMed DOI

View all evidence for Folate →