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Best L-Tryptophan 500 mg

product on market Capsule Doctor's Best Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 67% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

L-tryptophan serves as a precursor to serotonin, while vitamins B6 and niacin act as cofactors in neurotransmitter synthesis. There is moderate evidence supporting these ingredients for mood and sleep regulation. The current evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Best L-Tryptophan 500 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
90
Servings
Botanical with Nutrients
Product Type
67%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

20 mg (100% DV)
1.4× RDA — within safe limits 196 studies (A:5, B:63)
10 mg (500% DV)
7.7× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
500 mg
Market median: 500.0mg (70 products)

Other Ingredients

Modified Cellulose Cellulose Magnesium Stearate Silicon Dioxide
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Adult Use: Take 1 or 2 capsules daily. For optimum absorption, take separately from protein-containing foods and dietary supplements containing protein or amino acids.

Formulation Notes

Featuring Ajinomoto's TryptoPure(TM)

500mg L-Tryptophan

Suitable for Vegetarians

Enhanced With Vit.B6 & Niacinamide

Additional Information

R 10/10

USP Pharmaceutical Grade

CONTAINS NOTHING OTHER THAN LISTED INGREDIENTS

AJIPURE(TM) AMINO ACIDS

L-tryptophan is an essential amino acid (protein building block) in human nutrition. Essential amino acids are not synthesized by the body and must be obtained in the diet. The L-tryptophan in this product is manufactured and tested for purity according to the Japanese Pharmacopeia (JP) and the United States Pharmacopeia (USP) standards. Vitamin B6 is an essential cofactor in the conversion of tryptophan, while niacinamide plays an important role in allowing our body to properly utilize this essential amino acid.

Metadata

Product Details

UPC / SKU7 53950 00161 9
DSLD Entry Date2013-09-25
Product TypeBotanical with Nutrients
FormCapsule
BrandDoctor's Best
DSLD ID25210
Data Updated2026-04-11
Research

Research Evidence

29
Research Sources
48
Avg Quality
19
Rct
5
Meta Analysis
3
Systematic Review
2
Clinical Trial
B Prebiotic and probiotic supplementation and the tryptophan-kynurenine pathway: A systematic review and meta analysis
Meta Analysis Neuroscience and biobehavioral reviews 2021 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression
Meta Analysis Nutrition reviews 2022 PubMed DOI
B No effects of acute tryptophan depletion on anxiety or mood in weight-recovered female patients with anorexia nervosa
Rct European archives of psychiatry and clinical neuroscience 2023 PubMed DOI
C The association between tryptophan levels and postpartum mood disorders: a systematic review and meta-analysis
Meta Analysis BMC psychiatry 2022 PubMed DOI
C A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning
Systematic Review Journal of dietary supplements 2021 PubMed DOI
C Comparison between Acupuncture and Nutraceutical Treatment with Migratens® in Patients with Fibromyalgia Syndrome: A Prospective Randomized Clinical Trial.
Rct Nutrients PubMed DOI
C Intake of Lactiplantibacillus plantarum HEAL9 Improves Cognition in Moderately Stressed Subjects: A Randomized Controlled Study.
Rct Nutrients PubMed DOI
C Are tryptophan and 5-hydroxytryptophan effective treatments for depression? A meta-analysis
Meta Analysis The Australian and New Zealand journal of psychiatry 2002 PubMed
View all evidence for Tryptophan →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.