Best L-Tryptophan 500 mg by Doctor's Best — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Capsule(s) Serving Size

90 Servings

Botanical with Nutrients Product Type

67% Evidence Coverage

Supplement Facts — Evidence Check

Niacin

20 mg (100% DV)

✅ 1.4× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 20mg UL 35mg

Vitamin B6

10 mg (500% DV)

📊 7.7× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 10mg UL 100mg

L-Tryptophan

500 mg

📊 Market median: 500.0mg (70 products)

Median 500.0mg This product: 500mg

Other Ingredients

Modified Cellulose Cellulose Magnesium Stearate Silicon Dioxide

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (90% of products) Nutrient (61% of products)

Target Groups

Vegetarian Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Suggested Adult Use: Take 1 or 2 capsules daily. For optimum absorption, take separately from protein-containing foods and dietary supplements containing protein or amino acids.

🧪 Formulation Notes

Featuring Ajinomoto's TryptoPure(TM)

500mg L-Tryptophan

Suitable for Vegetarians

Enhanced With Vit.B6 & Niacinamide

Additional Information

R 10/10

USP Pharmaceutical Grade

CONTAINS NOTHING OTHER THAN LISTED INGREDIENTS

AJIPURE(TM) AMINO ACIDS

L-tryptophan is an essential amino acid (protein building block) in human nutrition. Essential amino acids are not synthesized by the body and must be obtained in the diet. The L-tryptophan in this product is manufactured and tested for purity according to the Japanese Pharmacopeia (JP) and the United States Pharmacopeia (USP) standards. Vitamin B6 is an essential cofactor in the conversion of tryptophan, while niacinamide plays an important role in allowing our body to properly utilize this essential amino acid.

Product Details

UPC / SKU 7 53950 00161 9

DSLD Entry Date 2013-09-25

Product Type Botanical with Nutrients

Form Capsule

Brand Doctor's Best

DSLD ID 25210

Data Updated 2026-04-11

Research Evidence

29 Research Sources

48 Avg Quality Score

19 Rct

5 Meta Analysis

3 Systematic Review

2 Clinical Trial

B Prebiotic and probiotic supplementation and the tryptophan-kynurenine pathway: A systematic review and meta analysis

Meta Analysis Neuroscience and biobehavioral reviews 2021

PubMed DOI

B Tryptophan and 5-hydroxytryptophan for depression

Systematic Review The Cochrane database of systematic reviews 2001

PubMed Cochrane

B Tryptophan and 5-hydroxytryptophan for depression

Systematic Review The Cochrane database of systematic reviews 2002

PubMed Cochrane

B The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression

Meta Analysis Nutrition reviews 2022

PubMed DOI

B No effects of acute tryptophan depletion on anxiety or mood in weight-recovered female patients with anorexia nervosa

Rct European archives of psychiatry and clinical neuroscience 2023

PubMed DOI

C The association between tryptophan levels and postpartum mood disorders: a systematic review and meta-analysis

Meta Analysis BMC psychiatry 2022

PubMed DOI

C A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning

Systematic Review Journal of dietary supplements 2021

PubMed DOI

C Comparison between Acupuncture and Nutraceutical Treatment with Migratens® in Patients with Fibromyalgia Syndrome: A Prospective Randomized Clinical Trial.

Rct Nutrients

PubMed DOI

C Intake of Lactiplantibacillus plantarum HEAL9 Improves Cognition in Moderately Stressed Subjects: A Randomized Controlled Study.

Rct Nutrients

PubMed DOI

C Are tryptophan and 5-hydroxytryptophan effective treatments for depression? A meta-analysis

Meta Analysis The Australian and New Zealand journal of psychiatry 2002

PubMed

View all evidence for Tryptophan →