🟢 80/100

This product is generally safe

  • Methyl Folate: 1000mg is 1000.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Methyl Folate: 1000mg is 1000.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Capsule(s) Serving Size
240 Servings
Other Combinations Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

1000 mcg DFE (250% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1000.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 1000mg UL 1.0mg
📊 Market median: 500.0mg (180 products) 📚 5 studies (Tier A: 0, B: 1)
This product: 150mg

Other Ingredients

Gelatin Capsule

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Suggested use consume one or more capsules daily or as recommended by your physician. As with any dietary supplement, this product is most effective as part of a healthy diet and active lifestyle. For questions about the use of this product call 800.332.7799.

⚠️ Warnings & Precautions

Contains no additives or common allergens of any kind

🧪 Formulation Notes

For over 40 years unsurpassed purity, quality and efficacy 100% solar production Zero carbon footprint

All solar

1,000 mcg Methyltetrahydrofolate-5-MTHF Naturally active form of Folic Acid

Andrew Lessman's Methyl Folate 1000 delivers 1,000 mcg of 5-methyltetrahydrofolate (5-MTHF or Methyl Folate) - the active form of Vitamin B9, an essential B-vitamin also known as Folic Acid.

Although often mistakenly viewed as a secondary B-vitamin, Folic Acid is required for the body's most critical functions, such as all cell replication, repair and DNA synthesis, making it essential during pregnancy and to support the health of our body's most vital organs and systems (heart, brain and immune). Plus, Methyl Folate can cross the blood-brain barrier, where it can deliver its brain and mood supportive benefits directly to the nervous system. Folic Acid is the typical form of Vitamin B9 found in supplements and fortified foods, but it must be converted to 5-MTHF to deliver its benefits. Unfortunately, a substantial percentage of Americans cannot convert Folic Acid into its active form and are thus deprived of its vital benefits. Our Methyl Folate (5-MTHF) already exists in its active form and can deliver its benefits to everyone without requiring any difficult or impossible chemical conversion. In short, our Methyl Folate 1000 overcomes the all too common biochemical obstacles that prevent so many of us from enjoying the critical benefits of this essential B-vitamin.

Contains no additives or common allergens of any kind

Additional Information

We remain uniquely committed to you and the planet. You have my unwavering promise. Andrew Lessman, founder Questions?/reorders? 800.800.1200 www.ProCapsLabs.com www.HSN.com 800.944.9999 www.QVC.com 800.345.1515

Product Details

UPC / SKU 712540
DSLD Entry Date 2021-05-22
Product Type Other Combinations
Form Capsule
Brand ProCaps
DSLD ID 248078
Data Updated 2026-04-11

Research Evidence

363 Research Sources
57 Avg Quality Score
187 Meta Analysis
56 Systematic Review
54 Rct
29 Guideline
26 Clinical Trial
6 Cochrane Review
2 Regulatory Source
1 Other
1 Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025
View all evidence for Folate →

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