🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 14% of ingredients have research evidence
B Label Compliance Grade

Product Label

📸

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Label Data

4 Capsule(s) Serving Size
30 Servings
Other Combinations Product Type
14% Evidence Coverage

Supplement Facts — Evidence Check

DL-Phenylalanine
500 mg
📊 Market median: 300.0mg (240 products) 📚 11 studies — no high-quality reviews
This product: 300mg
Jujube
200 mg
California Poppy
200 mg
Passion flower
200 mg
Skullcap
200 mg
150 mg
📊 Market median: 300.0mg (122 products) 📚 22 studies (Tier A: 0, B: 7)
This product: 150mg

Other Ingredients

Vegetarian Capsule Cellulose Silica Magnesium Stearate

Label Claims — Verification

All Other
All Other (99% of products) Structure/Function (78% of products) Nutrient (2% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Suggested use for adults: Two capsules twice daily, away from meals, or as directed by your health care practitioner.

⚠️ Warnings & Precautions

Warning: Do not use if pregnant, or with MAO inhibitors. If you are pregnant, trying to become pregnant, nursing, or taking any drugs or medications consult your physician before taking. St. John's Wort may cause undesirable reactions when combined with certain drugs or prescription medications.

Notice: Avoid excessive exposure to UV irradiation (e.g., sunlight; tanning) when using this product.

🧪 Formulation Notes

Herbal Concentrate with DL-Phenylalanine

Additional Information

KARUNA(R) RESPONSIBLE NUTRITION(TM)

Keep in a cool, dry place, tightly capped.

5125-lb4

Product Details

DSLD Entry Date 2013-08-23
Product Type Other Combinations
Form Capsule
Brand Karuna
DSLD ID 24763
Data Updated 2026-04-11

Research Evidence

43 Research Sources
48 Avg Quality Score
16 Meta Analysis
14 Systematic Review
7 Rct
4 Regulatory Source
1 Clinical Trial
1 Openfda Safety
B St John's wort for major depression
Systematic Review The Cochrane database of systematic reviews 2008
B Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis
Meta Analysis Journal of affective disorders 2017
B A systematic review of St. John's wort for major depressive disorder
Meta Analysis Systematic reviews 2016
B St John's wort for depression
Systematic Review The Cochrane database of systematic reviews 2000
B Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Meta Analysis Neuropsychopharmacology reports 2025
B St John's wort for depression
Meta Analysis The Cochrane database of systematic reviews 2005
C St John's wort for depression: meta-analysis of randomised controlled trials
Meta Analysis The British journal of psychiatry : the journal of mental science 2005
C The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Rct Complementary therapies in medicine 2019
C Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks
Rct BMJ (Clinical research ed.) 1999
C Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis
Meta Analysis Scientific reports 2016
View all evidence for St Johns Wort →

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