🟢 95/100

This product looks safe

  • Vitamin B3: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)
  • 57% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Vitamin B3: 100mg is 2.9× the Tolerable Upper Intake Level (35mg)

Label Data

1 Tablet(s) Serving Size
60 Servings
Botanical with Nutrients Product Type
57% Evidence Coverage

Supplement Facts — Evidence Check

100 mg (500% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 2.9× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 100mg UL 35mg
50 mg (2500% DV)
📊 38.5× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 50mg UL 100mg
Calcium
75 mg (8% DV)
75 mg (19% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 75mg
175 mg
📊 Market median: 300.0mg (214 products) 📚 23 studies (Tier A: 0, B: 6)
This product: 175mg
Passion Flower
100 mg
100 mg
📊 Market median: 80.0mg (136 products)
Median 80.0mg This product: 100mg

Other Ingredients

Vegetable Stearine Cellulose

Label Claims — Verification

All Other
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Adult (18 - 50 Years) Dairy Free Sugar Free

Product Information

📋 Directions for Use

Suggested use for adults: Two tablets with breakfast and two more 30 minutes before bedtime.

⚠️ Warnings & Precautions

Caution: Not to be used by pregnant or lactating women or while operating heavy machinery.

🧪 Formulation Notes

Valerian/Passionflower Complex

This product contains no yeast, wheat, soy, corn, milk, salt, sugar, artificial coloring, preservatives or flavoring.

Additional Information

KARUNA(R) RESPONSIBLE NUTRITION(TM)

This product is intended for professional use and is manufactured under strict quality control to ensure the optimum in purity, potency and reliability.

Keep in a cool, dry place, tightly capped.

L907086E09/12

5114-LB3

Product Details

DSLD Entry Date 2013-08-23
Product Type Botanical with Nutrients
Form Tablet or Pill
Brand Karuna
DSLD ID 24761
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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