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HepatoPlex

product on market Tablet or Pill Karuna Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 29% of ingredients have research evidence
B Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This profile contains ingredients like milk thistle and artichoke leaf, which have moderate evidence for supporting liver function. Other components, such as fumitory and barberry, have more limited research regarding their efficacy. Overall, the evidence coverage for this specific combination of ingredients is low.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for HepatoPlex
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Tablet(s)
Serving Size
60
Servings
Other Combinations
Product Type
29%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Fumitory
250 mg
200 mg
Market median: 300.0mg (159 products)
200 mg
Market median: 500.0mg (234 products) 95 studies (A:0, B:35)
Artichoke leaf extract
200 mg
250 mg
Market median: 250.0mg (562 products) 55 studies (A:0, B:19)
200 mg
Market median: 500.0mg (193 products) 7 studies — no high-quality reviews
200 mg
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Magnesium Stearate Stearic Acid Silicon Dioxide Cellulose Dicalcium Phosphate
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Suggested use for adults: Two tablets twice daily, away from meals, or as directed by your health care practitioner.

Formulation Notes

This product contains no yeast, wheat, soy, corn, milk, salt, sugar, artificial coloring, preservatives or flavoring.

Additional Information

9109-LB4

KARUNA(R) RESPONSIBLE NUTRITION(TM)

Herbal and Lipotropic Complex

This product is intended for professional use and is manufactured under strict quality control to ensure the optimum in purity, potency and reliability.

Keep in a cool, dry place, tightly capped.

EXP11/2012 LOT9J724-0

Metadata

Product Details

DSLD Entry Date2013-08-23
Product TypeOther Combinations
FormTablet or Pill
BrandKaruna
DSLD ID24419
Data Updated2026-04-11
Research

Research Evidence

69
Research Sources
55
Avg Quality
34
Meta Analysis
26
Systematic Review
5
Rct
3
Clinical Trial
1
Openfda Safety
A Silymarin for adults with metabolic dysfunction-associated steatotic liver disease
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
B Evaluation of the effect of herbal agents as management of radiodermatitis in breast cancer patients: A systematic review and meta-analysis
Meta Analysis Japan journal of nursing science : JJNS 2024 PubMed DOI
B Efficacy of different interventions for nonalcoholic fatty liver disease: A meta-analysis of lifestyle modifications, silymarin, and medications
Meta Analysis Asia Pacific journal of clinical nutrition 2025 PubMed DOI
B Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases
Meta Analysis The Cochrane database of systematic reviews 2007 PubMed
B Pharmacotherapy for trichotillomania
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition ESPEN 2022 PubMed DOI
B Efficacy of traditional Chinese medicine combined with Silibinin on nonalcoholic fatty liver disease: A meta-analysis and systematic review
Meta Analysis Medicine 2024 PubMed DOI
B Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury
Meta Analysis BMC complementary medicine and therapies 2025 PubMed DOI
B The therapeutic effects of silymarin for patients with glucose/lipid metabolic dysfunction: A meta-analysis
Meta Analysis Medicine 2020 PubMed DOI
B Administration of silymarin in NAFLD/NASH: A systematic review and meta-analysis
Meta Analysis Annals of hepatology 2024 PubMed DOI
View all evidence for Milk Thistle →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.