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DuoZyme

product on market Capsule Karuna Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 14% of ingredients have research evidence
B Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula combines digestive enzymes like pancreatin, papsin, and papain with betaine HCl and glutamic acid to support protein breakdown and stomach acid levels. There is strong evidence supporting the efficacy of these ingredients for managing digestive insufficiency. However, overall evidence coverage for this specific combination remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for DuoZyme
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
45
Servings
Non-Nutrient/Non-Botanical
Product Type
14%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

300 mg
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
Market median: 4002.0mg (1 products) 21 studies (A:0, B:2)
Papain
100 mg
Pepsin
40 mg
Pancreatin
300 mg
Ox Bile extract
120 mg
Providing at least the following

Other Ingredients

Capsule Silica Stearic Acid Vegetable Stearate Maltodextrin
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Suggested use for adults: Two or more capsules, taken with meals, or as directed by your health care practitioner.

Warnings & Precautions

Patients with active peptic ulcer should use HCl products with caution.

Additional Information

KARUNA(R) RESPONSIBLE NUTRITION(TM)

This product is intended for professional use and is manufactured under strict quality control to ensure the optimum in purity, potency and reliability.

Keep in a cool, dry place, tightly capped.

Fast-acting, Full Range Digestive Enzymes

Metadata

Product Details

DSLD Entry Date2013-08-23
Product TypeNon-Nutrient/Non-Botanical
FormCapsule
BrandKaruna
DSLD ID24362
Data Updated2026-04-11
Research

Research Evidence

23
Research Sources
47
Avg Quality
18
Rct
3
Systematic Review
1
Meta Analysis
1
Clinical Trial
B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
Rct Nutrients 2016 PubMed DOI
C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
Rct Hepatology (Baltimore, Md.) 2009 PubMed DOI
C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
Systematic Review Journal of inherited metabolic disease 2017 PubMed DOI
C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines
Systematic Review Journal of inherited metabolic disease 2015 PubMed DOI
C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
Rct European journal of nutrition 2023 PubMed DOI
C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis
Meta Analysis International orthodontics 2019 PubMed DOI
C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct The American journal of clinical nutrition PubMed DOI
C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
Rct Clinical nutrition ESPEN PubMed DOI
C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct The American journal of clinical nutrition PubMed DOI
C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine
Rct Cardiovascular drugs and therapy 2009 PubMed DOI
View all evidence for Betaine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.