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Folinic-Plus

product on market Other (e.g. tea bag) Pro-Pharma Safety: 87/100
87/100

This product is generally safe

  • Folinic Acid: 4mg is 4.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Folinic acid, methylcobalamin, and pyridoxal 5-phosphate provide essential B-vitamin support for cellular metabolism and neurological function. There is strong evidence supporting the role of these bioactive forms in supporting homocysteine levels and cognitive health. The ingredient profile is generally well-tolerated, though individual responses to B-vitamin supplementation may vary.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folinic Acid: 4mg is 4.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Folinic-Plus
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Caplet(s)
Serving Size
90
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

50 mg (2750% DV)
38.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
4 mg (944% DV)
Exceeds UL by 4.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
2 mg (40083% DV)
833.3× RDA — above typical dose 139 studies (A:1, B:44)

Other Ingredients

Microcrystalline Cellulose Croscarmellose Sodium Magnesium Stearate Silicon Dioxide
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Dosage and administration One caplet daily or as prescribed by a physician.

Warnings & Precautions

Warning: In case of accidental overdose, call a doctor or poison control center immediately.

Keep this and all drugs out of the reach of children.

Formulation Notes

Allergen statement: This product contains none of the 8 major allergens (dairy, egg, fish, shellfish, tree nuts, peanuts, soy or gluten).

Vitamin B6, B9 & B12

Dye free

Expect mild variations in color from shade of yellow to light pink. Made in the USA

Additional Information

Store at controlled room temperature 15 degrees-30 degrees C (59 degrees-86 degrees F)

N

66594-692-90

Metadata

Product Details

UPC / SKU3 66594 69290 9
DSLD Entry Date2020-12-26
Product TypeVitamin
FormOther (e.g. tea bag)
BrandPro-Pharma
DSLD ID240310
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.