🟢 87/100

This product is generally safe

  • Niacin: 375mg is 10.7× the Tolerable Upper Intake Level (35mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 36% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 375mg is 10.7× the Tolerable Upper Intake Level (35mg)
ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

2 Tablet(s) Serving Size
60 Servings
Other Combinations Product Type
36% Evidence Coverage

Supplement Facts — Evidence Check

375 mg (2344% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 10.7× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 375mg UL 35mg
65 mg (12% DV)
✅ Within RDA (0.1× RDA of 550 mg) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 65mg UL 3500mg
Lecithin Complex
450 mg
Phytosterol Complex
200 mg
Glycosaminoglycan Complex
150 mg
85 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 85mg
50 mg
📊 Market median: 200.0mg (136 products) 📚 3 studies — no high-quality reviews
This product: 50mg
Papain
50 mg
📊 Market median: 500.0mg (283 products) 📚 173 studies (Tier A: 0, B: 62)
This product: 50mg
5 mg
📊 Market median: 500.0mg (19 products)
This product: 5mg
Proprietary Blend
150 mg

Other Ingredients

Microcrystalline Cellulose Croscarmellose Sodium Stearic Acid Vegetable Stearate Tablet Coating Silica

Label Claims — Verification

All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free

Product Information

📋 Directions for Use

Suggested Usage: As a dietary supplement, adults take 2 tablets twice daily or as directed by your health professional.

⚠️ Warnings & Precautions

Warning: Not to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if seal is intact.

Contains: Soy

🧪 Formulation Notes

Gluten-free, non-GMO

Support for healthy fat and cholesterol metabolism

Additional Information

Store in a cool, dry place.

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our manufacturing excellence

Product Details

UPC / SKU 3 10539 01350 2
DSLD Entry Date 2020-08-23
Product Type Other Combinations
Form Tablet or Pill
DSLD ID 233002
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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