🟢 84/100

This product is generally safe

  • Folate: 333mg is 333.0× the Tolerable Upper Intake Level (1.0mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 50% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 333mg is 333.0× the Tolerable Upper Intake Level (1.0mg)
ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

11 Gram(s) Serving Size
30 Servings
Other Combinations Product Type
50% Evidence Coverage

Supplement Facts — Evidence Check

Calories
30 Calorie(s)
Total Carbohydrates
5 Gram(s) (2% DV)
4 mg (235% DV)
📊 3.1× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 4mg UL 100mg
333 mcg DFE (83% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 333.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 333mg UL 1.0mg
12 mcg (500% DV)
📊 5.0× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.012mg
Proprietary Blend
5.6 Gram(s)

Other Ingredients

Citric Acid Erythritol Maltodextrin natural Fruit flavors natural Citrus Sweetener Silicon Dioxide Beet root juice concentrate Stevia Leaf Extract

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (98% of products) Structure/Function (89% of products) Nutrient (43% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating)

Product Information

📋 Directions for Use

Directions: Mix 1 serving (1 packet) with 4-8 oz. water (depending on individual taste). Stir to dissolve. If water is very cold, mixture will take about one minute to dissolve. One serving (1 packet) may be taken twice per day.

⚠️ Warnings & Precautions

Consult your physician prior to use if you have a preexisting medical condition including myocardial infarction (heart attack), cardiovascular disease, or diabetes, or take medications for any reason including erectile dysfunction. Not recommended for use in children or pregnant or lactating women.

Not recommended for use in children or pregnant or lactating women.

🧪 Formulation Notes

L-Arginine Complexer

Slight color changes may occur over time due to the natural fruit flavor. There is not change in the efficacy or potency of the product.

ProArgi-9+ Active helps support cardiovascular health and enhance blood circulation.

The advanced research behind ProArgi-9+ Active combines the heart health benefits of L-Arginine to give the extra boost you need to be active. And with the added benefits of vitamin B6 and B12, folic acid, and D-ribose, ProArgi-9+ Active is a complete formula to enhance your heart health.

Additional Information

Store in a cool, dry place.

Product Details

DSLD Entry Date 2020-04-23
Product Type Other Combinations
Form Other (e.g. tea bag)
Brand Synergy
DSLD ID 217172
Data Updated 2026-04-11

Research Evidence

153 Research Sources
55 Avg Quality Score
71 Systematic Review
51 Meta Analysis
19 Rct
6 Clinical Trial
2 Other
2 Regulatory Source
1 Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022
View all evidence for Vitamin B6 →

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