Home/ Supplements/ Same/ SAMe (S-Adenosyl-L-Methionine) 200 mg

SAMe (S-Adenosyl-L-Methionine) 200 mg

product on market Tablet or Pill Solgar Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

S-Adenosyl-L-Methionine (SAMe) is used to support mood and joint health. There is moderate evidence suggesting its efficacy in managing depressive symptoms and osteoarthritis. However, overall evidence coverage for this specific formulation remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAMe (S-Adenosyl-L-Methionine) 200 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

200 mg
Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Vegetable Cellulose Mannitol Methacrylic Acid Citric Acid Glyceryl Triacetate Stearic Acid Silica Titanium Dioxide
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Suggested Use: As a dietary supplement for adults, take one (1) tablet daily with a carbohydrate snack, or as directed by a healthcare practitioner.

Warnings & Precautions

Do not use if outer bottle seal is missing, torn or damaged in any way.

If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Keep out of reach of children.

This product should not be used by individuals with bipolar disorder. If you are taking anti-depressant drugs (such as MAOI's or SSRI's) consult your doctor before taking.

Formulation Notes

Solgar's SAMe (S-Adenosyl-L-Methionine) Tablets are free of corn, yeast, wheat, soy, dairy products and gluten and are formulated without the use of artificial preservatives, flavors or colors.

S-Adenosyl-L-Methionine is an important sulfur-containing amino acid derivative.

Solgar's KOF-K certification #K-1250

Enteric coated

Suitable for vegetarians

Sugar and starch free

Additional Information

To assure freshness and potency, store at room temperature 59 degrees-86 degrees F (15 degrees-30 degrees C). Store away from heat, light and moisture.

Solgar since 1947

K Parve (Kosher)

Metadata

Product Details

UPC / SKU0 33984 02488 5
DSLD Entry Date2020-03-24
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
BrandSolgar
DSLD ID214933
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
View all evidence for Same →
Compare

Similar Products

View all Same products →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.