🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Tablet(s) Serving Size
Non-Nutrient/Non-Botanical Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

200 mg
📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)
This product: 200mg

Other Ingredients

Vegetable Cellulose Mannitol Methacrylic Acid Citric Acid Glyceryl Triacetate Stearic Acid Silica Titanium Dioxide

Label Claims — Verification

All Other
All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Kosher Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Suggested Use: As a dietary supplement for adults, take one (1) tablet daily with a carbohydrate snack, or as directed by a healthcare practitioner.

⚠️ Warnings & Precautions

Do not use if outer bottle seal is missing, torn or damaged in any way.

If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Keep out of reach of children.

This product should not be used by individuals with bipolar disorder. If you are taking anti-depressant drugs (such as MAOI's or SSRI's) consult your doctor before taking.

🧪 Formulation Notes

Solgar's SAMe (S-Adenosyl-L-Methionine) Tablets are free of corn, yeast, wheat, soy, dairy products and gluten and are formulated without the use of artificial preservatives, flavors or colors.

S-Adenosyl-L-Methionine is an important sulfur-containing amino acid derivative.

Solgar's KOF-K certification #K-1250

Enteric coated

Suitable for vegetarians

Sugar and starch free

Additional Information

To assure freshness and potency, store at room temperature 59 degrees-86 degrees F (15 degrees-30 degrees C). Store away from heat, light and moisture.

Solgar since 1947

K Parve (Kosher)

Product Details

UPC / SKU 0 33984 02488 5
DSLD Entry Date 2020-03-24
Product Type Non-Nutrient/Non-Botanical
Form Tablet or Pill
Brand Solgar
DSLD ID 214933
Data Updated 2026-04-11

Research Evidence

12 Research Sources
58 Avg Quality Score
8 Meta Analysis
3 Systematic Review
1 Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024
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