Home/ Supplements/ Folate/ Biofolate

Biofolate

product on market Capsule AOR Advanced Orthomolecular Research Premium Safety: 80/100
80/100

This product is generally safe

  • Folate: 1667mg is 1667.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Folate and Vitamin B12 are essential nutrients that support cellular repair and homocysteine regulation, with strong evidence supporting their role in neurological health. These ingredients are well-researched for maintaining red blood cell production and cognitive function. Current data indicates a high safety profile for these specific nutrients.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1667mg is 1667.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Biofolate
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
30
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1667 mcg DFE (417% DV)
Exceeds UL by 1667.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
2.8 mcg (117% DV)
1.2× RDA — within safe limits 139 studies (A:1, B:44)

Other Ingredients

Microcrystalline Cellulose Capsule Silicon Dioxide Sodium Stearyl Fumarate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 1 capsule daily with food, or as directed by a qualified health care practitioner.

Warnings & Precautions

Do not use if safety seal is broken

Caution: Consult your physician before use if you are pregnant, lactating, have a medical condition, or are taking any medication.

Folate supplement can mask any vitamin B12 deficiency.

Keep out of reach of children.

To report a serious adverse event or obtain product information, call 1-866-215-0450

Formulation Notes

GMP Manufacturing Quality assured Independent testing

Discussion: BioFolate contains the preferred, biologically active form of folic acid that is produced in the body along with methylated vitamin B12.

Bioactive folate & vitamin B12

Vegan

Non-GMO Gluten free

AOR guarantees that all ingredients have been declared on the label.

Made without wheat, gluten, corn, nuts, peanuts, sesame seeds, sulfites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Additional Information

Store tightly sealed in a cool, dry place

MyBlueprint

Product of Canada

Metadata

Product Details

UPC / SKU6 24917 08176 3
DSLD Entry Date2020-02-26
Product TypeVitamin
FormCapsule
BrandAOR Advanced Orthomolecular Research Premium
DSLD ID214432
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
View all evidence for Folate →
Compare

Similar Products

Bio-Plus Biotin With Folic Acid
Douglas Laboratories · Capsule
100
Folic Acid
OL Olympian Labs · Capsule
100
L-5-MTHF Natural S-Isomer
Designs for Health · Capsule
100
Folic Acid
DaVinci Laboratories Of Vermont · Capsule
100
SAMe with Vitamins B-6, B-12 and 5-MTHF
Designs for Health · Capsule
100
View all Folate products →
Folate research Best Folate All Folate products More from AOR Advanced Orthomolecular Research Premium View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.