🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size
360 Servings
Other Combinations Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

650 mg
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 650mg
Pepsin
Gentian
20 mg

Other Ingredients

Gelatin Silicon Dioxide Stearic Acid Magnesium Silicate

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (82% of products) Nutrient (8% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Suggested Adult Use: Take 1 capsule with food, three times daily, or as recommended by a nutritionally-informed physician.

⚠️ Warnings & Precautions

Warning: Consult with your physician before taking this product if you are pregnant, nursing, have a history of peptic ulcer or high blood pressure.

Avoid taking this product if you have been diagnosed with kidney problems.

🧪 Formulation Notes

Betaine HCl/Pepsin/Gentian Bitters contains three nutritional factors that perform complementary functions designed to support the efficiency of the digestive process.

Supplementing with Betaine HCl may support the stomach's digestive capacity. Pepsin is an enzyme produced by the body to digest protein containing foods in the stomach. Pepsin works in conjunction with stomach acid to support protein digestion. Gentian is an herb used to support digestive capacity and tonify the digestive tract. Its bitter nature may help to stimulate the body's production of digestive enzymes.

Helps support digestive efficiency

Non-GMO / Gluten Free

Additional Information

Science-Based Nutrition

Store in a cool dry place.

Product Details

UPC / SKU 7 53950 00315 6
DSLD Entry Date 2019-11-21
Product Type Other Combinations
Form Capsule
DSLD ID 209466
Data Updated 2026-04-11

Research Evidence

23 Research Sources
47 Avg Quality Score
18 Rct
3 Systematic Review
1 Meta Analysis
1 Clinical Trial
B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
Rct Nutrients 2016
C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial
Rct Hepatology (Baltimore, Md.) 2009
C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
Systematic Review Journal of inherited metabolic disease 2017
C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines
Systematic Review Journal of inherited metabolic disease 2015
C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial
Rct European journal of nutrition 2023
C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis
Meta Analysis International orthodontics 2019
C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.
Rct The American journal of clinical nutrition
C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.
Rct Clinical nutrition ESPEN
C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.
Rct The American journal of clinical nutrition
C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine
Rct Cardiovascular drugs and therapy 2009
View all evidence for Betaine →

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