SAMe
100/100
This product looks safe
- No ingredients exceed tolerable upper intake levels
- Limited research evidence available for ingredients
B
Label Compliance Grade
Label
Product Label
Details
Label Data
1 Tablet(s)
Serving Size
10
Servings
Non-Nutrient/Non-Botanical
Product Type
0%
Evidence Coverage
Ingredients
Supplement Facts — Evidence Check
400 mg
Market median: 500.0mg (193 products)
7 studies — no high-quality reviews
Other Ingredients
Cellulose
Mannitol
Methacrylic Acid Copolymer
Citric Acid
Stearic Acid
Silica
Titanium Dioxide
Hydroxypropyl Methylcellulose
Glyceryl Triacetate
Sodium Starch Glycolate
Croscarmellose Sodium
yellow Ochre
Claims
Label Claims — Verification
Unverified
All Other
Info
Product Information
Directions for Use
SAMe may be taken with item #72580 Homecysteine Plus with Setria Glutathione, and/or item #73230 TMG (Trimethylglycine).
Suggested use As a dietary supplement, 1 or 2 tablets one to three times daily between meals, or as directed by a healthcare practitioner.
Formulation Notes
SAMe, a natural form of bioactive methionine, in enteric-coated tablets.
(S-Adenosylmethionine) Bioactive Methionine
Hypoallergenic
Additional Information
Keep in a cool, dry place, tightly capped.
Metadata
Product Details
UPC / SKU7 13947 73190 5
DSLD Entry Date2019-11-21
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
DSLD ID208402
Data Updated2026-04-11
Research
Research Evidence
12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B
S-adenosyl-L-methionine for alcoholic liver diseases
B
S-adenosyl methionine (SAMe) for depression in adults
B
Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
B
SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
B
S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
B
S-adenosyl-L-methionine for alcoholic liver diseases
B
WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
C
S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
C
S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.