100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
Limited research evidence available for ingredients

B Label Compliance Grade

Label

Product Label

Open Full PDF View on NIH DSLD →

Details

Label Data

1 Capsule(s)

Serving Size

Non-Nutrient/Non-Botanical

Product Type

Evidence Coverage

Ingredients

Supplement Facts — Evidence Check

Betain

496 mg

Pepsin

140 mg

Other Ingredients

Cellulose Gelatin Vegetable Stearate

Claims

Label Claims — Verification

Unverified All Other

Info

Product Information

Directions for Use

Suggested Usage: As a dietary supplement, adults take as directed by a physician only.

Warnings & Precautions

Keep out of reach of children.

Tamper resistant package, do not use if outer seal is missing.

Formulation Notes

This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives or flavoring.

Digestive Enzyme Formula with Pepsin

Additional Information

For optimal storage conditions, store in a cool, dry place. (59-77degF/15-25degC) (35-65% relative humidity)

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Metadata

Product Details

DSLD Entry Date2013-02-25

Product TypeNon-Nutrient/Non-Botanical

FormCapsule

BrandMartin Avenue Pharmacy

DSLD ID18786

Data Updated2026-04-11

Research

Research Evidence

Research Sources

Avg Quality

Rct

Systematic Review

Meta Analysis

Clinical Trial

B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine

Rct Nutrients 2016 PubMed DOI

C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial

Rct Hepatology (Baltimore, Md.) 2009 PubMed DOI

C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency

Systematic Review Journal of inherited metabolic disease 2017 PubMed DOI

C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines

Systematic Review Journal of inherited metabolic disease 2015 PubMed DOI

C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial

Rct European journal of nutrition 2023 PubMed DOI

C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis

Meta Analysis International orthodontics 2019 PubMed DOI

C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.

Rct The American journal of clinical nutrition PubMed DOI

C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.

Rct Clinical nutrition ESPEN PubMed DOI

C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.

Rct The American journal of clinical nutrition PubMed DOI

C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine

Rct Cardiovascular drugs and therapy 2009 PubMed DOI

View all evidence for Betaine →

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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.