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N.O. Express

product on market Capsule Pure Advantage Safety: 90/100
90/100

This product looks safe

  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 75% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Niacinamide, Vitamin B6, and folic acid support metabolic function and cellular health with strong clinical evidence. The proprietary N.O. Muscle Matrix aims to enhance nitric oxide levels, though evidence for such blends is often limited. Overall, the profile is supported by a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Contains proprietary blend — exact ingredient amounts not disclosed

Label

Product Label

Label for N.O. Express
Open Full PDF View on NIH DSLD →
Details

Label Data

6 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
75%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

30 mg (150% DV)
2.1× RDA — within safe limits 196 studies (A:5, B:63)
10 mg (500% DV)
7.7× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
200 mcg (50% DV)
Within RDA (0.5× RDA) 226 studies (A:10, B:105)
Proprietary N.O. Muscle Matrix
4455 mg

Other Ingredients

Digeseb Plus Delivery System organic Rice Flour Magnesium Stearate Vegetable Capsules
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use on Training Days: As an adult dietary supplement, take 6 capsules on an empty stomach 30 to 60 minutes prior to exercise/athletic event. To achieve maximum results, always take on an empty stomach. Suggested Use on Non-Training Days: As an adult dietary supplement, take the first 3 capsules in the morning upon arising, then take the final 3 capsules before lunch. Important: To avoid sleeplessness, do not take within 4 hours of bedtime. Drink at least 1 gallon of water daily.

Warnings & Precautions

Warning: Do not use if you are pregnant or nursing.

Do not use if you are at risk or being treated for diabetes or low blood pressure.

Keep out of reach of children.

Important: To avoid sleeplessness, do not take within 4 hours of bedtime. Drink at least 1 gallon of water daily.

Formulation Notes

Does not contain any dairy, egg, sugar, corn, yeast, wheat, soy, glutens, artificial colors, flavors or preservatives.

Digeseb Plus is a proprietary blend of acid stable plant-based enzymes supplying (Amylase, Protease I, Protease II, Lipase, and Cellulase) for enhanced bioavailability.

GF Gluten-free

Additional Information

Store in a cool, dry place.

Nitric Oxide Booster for Increased Muscle Pumps

Made in a FDA registered facility Highest BIO availability

Made in USA GF Gluten-free

Metadata

Product Details

UPC / SKU6 46448 50019 3
DSLD Entry Date2018-09-21
Product TypeOther Combinations
FormCapsule
BrandPure Advantage
DSLD ID180797
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.