Home/ Supplements/ Vitamin B12/ Dual-Tox DPO

Dual-Tox DPO

product on market Capsule NuMedica Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 62% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains B-vitamins and folate, which have strong evidence for supporting methylation and metabolic processes. Artichoke leaf and watercress are included for their potential liver-supportive properties, though research evidence for these specific botanical extracts is more limited. The profile maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Dual-Tox DPO
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
62%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

50 mg (2500% DV)
38.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
800 mcg (200% DV)
2.0× RDA — within safe limits 226 studies (A:10, B:105)
200 mcg (3333% DV)
83.3× RDA — above typical dose 139 studies (A:1, B:44)
Artichoke leaf extract
600 mg
Watercress herb powder
500 mg
250 mg
Market median: 250.0mg (562 products) 55 studies (A:0, B:19)
Market median: 200.0mg (198 products) 6 studies — no high-quality reviews
NAC
200 mg
Market median: 600.0mg (7 products) 39 studies (A:2, B:13)
Market median: 4002.0mg (1 products) 21 studies (A:0, B:2)
150 mg
Market median: 260.0mg (249 products) 158 studies (A:4, B:61)
Ellagic Acid
100 mg
MSM
100 mg
Market median: 1000.0mg (2 products)
Market median: 4002.0mg (1 products) 21 studies (A:0, B:2)

Other Ingredients

HPMC MCC Rice Flour
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take two capsules twice daily or as directed by your healthcare practitioner.

Warnings & Precautions

Caution: Keep out of reach of children.

Professional use only

Formulation Notes

Contains no: Wheat, gluten, corn protein, yeast, soy, animal products, artificial colors, sweeteners or preservatives.

Additional Information

It has been formulated to contain select ingredients to support healthy detoxification and enhance the activities of hepatic detoxification enzymes. The term Dual Phase Optimizers (DPO) refers to those nutrients that have the ability to simultaneously influence and "optimize" the activity of certain Phase I enzymes as well as Phase II enzymes. By balancing and promoting these hepatoprotective properties these substances can favorably influence toxin metabolism and elimination.

Storage: Keep tightly closed in a cool, dry place.

Achieving physiological balance

Dual phase optimizers to support phase I & II detoxification Gold medallion formula

This formula meets or exceeds cGMP quality standards.

Vegetable capsules

This package is completely recyclable

Metadata

Product Details

UPC / SKU8 12527 01204 2
DSLD Entry Date2018-07-25
Product TypeOther Combinations
FormCapsule
BrandNuMedica
DSLD ID179606
Data Updated2026-04-11
Research

Research Evidence

237
Research Sources
53
Avg Quality
83
Meta Analysis
74
Systematic Review
45
Rct
29
Clinical Trial
2
Guideline
2
Regulatory Source
1
Openfda Safety
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression
Meta Analysis Nutrients 2021 PubMed DOI
A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Systematic Review Irish journal of medical science 2024 PubMed DOI
B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis
Meta Analysis BMJ open gastroenterology 2020 PubMed DOI
B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Systematic Review The Cochrane database of systematic reviews 2024 PubMed DOI
B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels
Meta Analysis Nutrition reviews 2024 PubMed DOI
B Relationship between vitamin B12 levels and motor development: A systematic review
Systematic Review Clinical nutrition ESPEN 2024 PubMed DOI
B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
Meta Analysis Frontiers in endocrinology 2023 PubMed DOI
View all evidence for Vitamin B12 →
Compare

Similar Products

Methyl B-12 5000 Micrograms
NutraBio · Capsule
100
Folic Acid & Vitamin B12 Caps
Life Extension · Capsule
100
Folate & Vitamin B12 Caps
Life Extension · Capsule
100
BioActive Folate & Vitamin B12
Life Extension · Capsule
100
Vitamin B 12 500 mcg
Solgar · Capsule
100
View all Vitamin B12 products →
Vitamin B12 research Best Vitamin B12 All Vitamin B12 products More from NuMedica View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.