Is 650 mg of Betaine HCl safe?

The recommended daily intake is None mg.

Betaine HCl Plus Pepsin by Bluebonnet

100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
Limited research evidence available for ingredients

B Label Compliance Grade

Label

Product Label

Open Full PDF View on NIH DSLD →

Details

Label Data

1 Capsule(s)

Serving Size

Non-Nutrient/Non-Botanical

Product Type

Evidence Coverage

Ingredients

Supplement Facts — Evidence Check

Betaine HCl

650 mg

Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Pepsin

130 mg

Other Ingredients

Kosher Vegetable Capsules Vegetable Cellulose Vegetable Magnesium Stearate

Claims

Label Claims — Verification

Unverified All Other

Unverified Structure/Function

Info

Product Information

Directions for Use

Directions: As a dietary supplement, take one capsule daily, preferably with a meal or as directed by a healthcare practitioner.

Warnings & Precautions

Caution: Do not use in cases of stomach pain or ulcers.

Formulation Notes

Bluebonnet’s Betaine HCl Plus Pepsin Capsules contain a special combination of betaine hydrochloride and pepsin, a digestive enzyme.

Made with non GMO ingredients

Free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat and soybeans. Also free of yeast, gluten, barley, rice, sodium and sugar.

Additional Information

Available in easy-to-swallow vegetable capsules for maximum assimilation and absorption.

0897D

Made with non GMO ingredients

Digestive health formula

Gluten free

Metadata

Product Details

UPC / SKU7 43715 00897 7

DSLD Entry Date2018-07-25

Product TypeNon-Nutrient/Non-Botanical

FormCapsule

BrandBluebonnet

DSLD ID178895

Data Updated2026-04-11

Research

Research Evidence

Research Sources

Avg Quality

Rct

Systematic Review

Meta Analysis

Clinical Trial

B Effect of Folic Acid, Betaine, Vitamin B₆, and Vitamin B12 on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine

Rct Nutrients 2016 PubMed DOI

C Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial

Rct Hepatology (Baltimore, Md.) 2009 PubMed DOI

C Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency

Systematic Review Journal of inherited metabolic disease 2017 PubMed DOI

C Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines

Systematic Review Journal of inherited metabolic disease 2015 PubMed DOI

C Effects of low-dose B vitamins plus betaine supplementation on lowering homocysteine concentrations among Chinese adults with hyperhomocysteinemia: a randomized, double-blind, controlled preliminary clinical trial

Rct European journal of nutrition 2023 PubMed DOI

C Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis

Meta Analysis International orthodontics 2019 PubMed DOI

C Two methods for assessment of choline status in a randomized crossover study with varying dietary choline intake in people: isotope dilution MS of plasma and in vivo single-voxel magnetic resonance spectroscopy of liver.

Rct The American journal of clinical nutrition PubMed DOI

C Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention.

Rct Clinical nutrition ESPEN PubMed DOI

C Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.

Rct The American journal of clinical nutrition PubMed DOI

C Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine

Rct Cardiovascular drugs and therapy 2009 PubMed DOI

View all evidence for Betaine →

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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.