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SAMe Gold 400 mg

product on market Tablet or Pill OL Olympian Labs Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

SAMe is researched for its potential to support mood regulation and joint health. There is moderate evidence suggesting its efficacy in managing depressive symptoms and osteoarthritis. However, overall evidence coverage for this specific formulation remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAMe Gold 400 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
30
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

400 mg
Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Cellulose Mannitol Hydroxypropylmethylcellulose-Phthalate Citric Acid Sodium Starch Glycolate Triacetin Croscarmellose Sodium Stearic Acid Silica yellow Ochre
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: As a dietary supplement, take one (1) or two (2) tablets daily, or as directed by a health care professional.

Warnings & Precautions

Warning: Individuals using standard antidepressants, such as MAO inhibitors, SSRI's and tricyclics should consult a physician before using this dietary supplement.

Individuals with Parkinson's Disease or Bipolar Disorder should not use SAMe.

Pregnant or nursing women should consult with their physician before using this product. Caution: If you are pregnant or nursing, have a medical condition, consult your healthcare professional before using this or any other nutritional supplement.

Discontinue use if allergic reaction occurs.

Keep out of reach of children.

Formulation Notes

No: Milk, eggs, fish, crustaceans shellfish, tree nuts, peanuts, wheat, or soybeans.

Vegan

Allergen free Gluten free Non-GMO

SAMe Gold 400 mg per serving

Additional Information

SAMe Gold may be beneficial for sufferers of depression, arthritis, fibromyalgia, migraines and may aid in liver function. SAMe is essential for the production of glutathione, a powerful antioxidant that protects the body from the damaging effects of free radicals. SAMe improves the binding of neurotransmitters to their receptor sites in the brain. SAMe has been used in Europe for the treatment of cirrhosis and for the damage caused by alcohol consumption. SAMe Gold may also be useful for depression.

General Information: SAMe (S-Adenosyl-L-Methionine), is formed by an enzymatic reaction of methionine, a sulfur-containing amino acid, and adenosine triphosphate (ATP), the body's main energy molecule. SAMe occurs naturally in the human body and is involved in over forty biochemical reactions in the body. Unfortunately, SAMe levels decline with age. Supplementing with additional SAMe may protect the body from immune deficiencies.

We do not use ingredients that were produced using modern biotechnology.

Pharmaceutical grade

Promotes healthy joint function Elevates mood and emotional well-being May help detoxify the liver

REV 01-20-16

Olympian Labs, Inc. products are made with the highest quality ingredients and manufactured according to current Good Manufacturing Practices (cGMP).

Made in USA

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU7 10013 03265 2
DSLD Entry Date2018-05-24
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
DSLD ID175996
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.