🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 36% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

2 Capsule(s) Serving Size
60 Servings
Other Combinations Product Type
36% Evidence Coverage

Supplement Facts — Evidence Check

Calories
15 {Calories}
Calories from Fat
15 {Calories}
Total Fat
1.5 g (2% DV)
50 mg (2500% DV)
📊 38.5× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 50mg UL 100mg
100 mcg (1667% DV)
📊 41.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.1mg
Calcium
200 mg (20% DV)
100 mg (25% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 100mg
Evening Primrose Oil
300 mg
📊 Market median: 80.0mg (136 products)
Median 80.0mg This product: 40mg
📊 Market median: 60.0mg (94 products) 📚 13 studies (Tier A: 0, B: 7)
This product: 125mg
Isolase(R)
35 mg

Other Ingredients

Soybean Oil Gelatin Glycerin Caramel color Titanium Dioxide

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (89% of products) Nutrient (56% of products)

Target Groups

Menopause Seniors/Mature (>50 Years) - Women ONLY Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, take two softgel capsules daily.

⚠️ Warnings & Precautions

KEEP OUT OF REACH OF CHILDREN.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication or have a medical condition. Discontinue use two weeks prior to surgery.

🧪 Formulation Notes

For support of common menopause symptoms*

No Sugar, No Artificial Flavors, No Preservatives, Sodium Free, No Gluten, No Dairy, Yeast Free.

Additional Information

Store in a cool, dry place.

ACTUAL SIZE

CODE 312921 DKG

Conforms to USP <2091> for weight.

GNC GUARANTEE Use any GNC supplement for as little as 10 days. If you are not 100% completely satisfied, return the unused portion of the product with proof of purchase to your GNC store for a complete refund of your purchase price. No questions asked!

GNC QUALITY COMMITMENT GNC, the leader in the development and manufacture of dietary supplements, is committed to producing the highest quality products available. This commitment begins with quality designed supplement formulations. Every raw material that goes into a GNC supplement is guaranteed as to quality and potency. Each product is dated and then shipped immediately to our stores, so you can be sure you are purchasing the freshest supplements available. At GNC, we extend out quality commitment to you by offering our money-back guarantee.

Meets USP <2040> disintegration.

Please recycle this box.

Product Details

DSLD Entry Date 2011-10-26
Product Type Other Combinations
Form Softgel Capsule
Brand GNC Women's
DSLD ID 1055
Data Updated 2026-04-11

Research Evidence

237 Research Sources
53 Avg Quality Score
83 Meta Analysis
74 Systematic Review
45 Rct
29 Clinical Trial
2 Guideline
2 Regulatory Source
1 Openfda Safety
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Systematic Review The Cochrane database of systematic reviews 2018
A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression
Meta Analysis Nutrients 2021
A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Systematic Review Irish journal of medical science 2024
B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis
Meta Analysis BMJ open gastroenterology 2020
B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Systematic Review The Cochrane database of systematic reviews 2024
B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels
Meta Analysis Nutrition reviews 2024
B Relationship between vitamin B12 levels and motor development: A systematic review
Systematic Review Clinical nutrition ESPEN 2024
B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
Meta Analysis Frontiers in endocrinology 2023
View all evidence for Vitamin B12 →

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