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Phyto-Estrogen Formula

product on market Softgel Capsule GNC Women's Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 36% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains B-vitamins, including B6 and B12, which are essential for metabolic function and neurological health. Research provides strong evidence for the role of these vitamins in supporting energy production. However, overall evidence coverage for the specific ingredient profile is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Phyto-Estrogen Formula
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
36%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
15 {Calories}
Calories from Fat
15 {Calories}
Total Fat
1.5 g (2% DV)
50 mg (2500% DV)
38.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
100 mcg (1667% DV)
41.7× RDA — above typical dose 139 studies (A:1, B:44)
Calcium
200 mg (20% DV)
100 mg (25% DV)
Within RDA (0.2× RDA) 316 studies (A:8, B:159)
Evening Primrose Oil
300 mg
Market median: 80.0mg (136 products)
Market median: 60.0mg (94 products) 13 studies (A:0, B:7)
Isolase(R)
35 mg

Other Ingredients

Soybean Oil Gelatin Glycerin Caramel color Titanium Dioxide
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take two softgel capsules daily.

Warnings & Precautions

KEEP OUT OF REACH OF CHILDREN.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication or have a medical condition. Discontinue use two weeks prior to surgery.

Formulation Notes

For support of common menopause symptoms*

No Sugar, No Artificial Flavors, No Preservatives, Sodium Free, No Gluten, No Dairy, Yeast Free.

Additional Information

Store in a cool, dry place.

ACTUAL SIZE

CODE 312921 DKG

Conforms to USP <2091> for weight.

GNC GUARANTEE Use any GNC supplement for as little as 10 days. If you are not 100% completely satisfied, return the unused portion of the product with proof of purchase to your GNC store for a complete refund of your purchase price. No questions asked!

GNC QUALITY COMMITMENT GNC, the leader in the development and manufacture of dietary supplements, is committed to producing the highest quality products available. This commitment begins with quality designed supplement formulations. Every raw material that goes into a GNC supplement is guaranteed as to quality and potency. Each product is dated and then shipped immediately to our stores, so you can be sure you are purchasing the freshest supplements available. At GNC, we extend out quality commitment to you by offering our money-back guarantee.

Meets USP <2040> disintegration.

Please recycle this box.

Metadata

Product Details

DSLD Entry Date2011-10-26
Product TypeOther Combinations
FormSoftgel Capsule
BrandGNC Women's
DSLD ID1055
Data Updated2026-04-11
Research

Research Evidence

237
Research Sources
53
Avg Quality
83
Meta Analysis
74
Systematic Review
45
Rct
29
Clinical Trial
2
Guideline
2
Regulatory Source
1
Openfda Safety
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression
Meta Analysis Nutrients 2021 PubMed DOI
A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Systematic Review Irish journal of medical science 2024 PubMed DOI
B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis
Meta Analysis BMJ open gastroenterology 2020 PubMed DOI
B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Systematic Review The Cochrane database of systematic reviews 2024 PubMed DOI
B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels
Meta Analysis Nutrition reviews 2024 PubMed DOI
B Relationship between vitamin B12 levels and motor development: A systematic review
Systematic Review Clinical nutrition ESPEN 2024 PubMed DOI
B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
Meta Analysis Frontiers in endocrinology 2023 PubMed DOI
View all evidence for Vitamin B12 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.