Maximum Strength B12 5,000 mcg by Nature Made — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
100% of ingredients have research evidence

A Label Compliance Grade

Product Label

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Label Data

1 Softgel(s) Serving Size

Vitamin Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin B12

5000 mcg (83333% DV)

📊 2083.3× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 5.0mg

Other Ingredients

Soybean Oil Gelatin Glycerin yellow Beeswax Water Colors added Soy Lecithin

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (89% of products) Nutrient (56% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Suggested use: Use only as directed by a healthcare professional. Take 1 softgel daily with a meal. For easier swallowing, take with water before and during ingestion.

⚠️ Warnings & Precautions

Caution: Do not exceed one softgel daily unless recommended by your healthcare professional; do not take longer than recommended by your healthcare professional.

Store in a cool, dry place, out of reach of children.

Do not use if imprinted seal under cap is broken or missing.

🧪 Formulation Notes

Maximum Strength B12 5,000 mcg

Maximum strength for adults diagnosed with very low levels of vitamin B12

Nature Made Maximum Strength B12 provides 5,000 mcg of vitamin B12, a nutrient essential in supporting optimal health

Colors derived from natural sources - No synthetic dyes No artificial flavors No preservatives No yeast or starch Gluten free

Additional Information

List No: 2886 L203 Cat. A686 5A004

#1 pharmacist recommended

USP Dietary Supplement Verified

Supports cellular energy production in the body Essential for proper red blood cell formation Helps support healthy homocysteine levels which may help support vascular health Helps support normal nervous system function Maximum 5,000 mcg - Helps restore healthy levels of B12 in adults with very low levels, as diagnosed by their healthcare professional using appropriate biomarkers. For more information, visit NatureMade.com.

Keep bottle tightly closed. Store in a cool, dry place, out of reach of children.

For those with vitamin B12 deficiency.

USP has tested and verified ingredients, potency, and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org. Based on Pharmacy Times Survey of pharmacists recommending Letter Vitamin Supplements.

Product Details

UPC / SKU 0 31604 02886 2

DSLD Entry Date 2018-09-21

Product Type Vitamin

Form Softgel Capsule

Brand Nature Made

DSLD ID 179932

Data Updated 2026-04-11

Research Evidence

237 Research Sources

53 Avg Quality Score

83 Meta Analysis

74 Systematic Review

45 Rct

29 Clinical Trial

2 Guideline

2 Regulatory Source

1 Openfda Safety

A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis

Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025

PubMed DOI

A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies

Meta Analysis Critical reviews in food science and nutrition 2019

PubMed DOI

A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency

Systematic Review The Cochrane database of systematic reviews 2018

PubMed DOI Cochrane

A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression

Meta Analysis Nutrients 2021

PubMed DOI

A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis

Systematic Review Irish journal of medical science 2024

PubMed DOI

B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis

Meta Analysis BMJ open gastroenterology 2020

PubMed DOI

B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes

Systematic Review The Cochrane database of systematic reviews 2024

PubMed DOI Cochrane

B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels

Meta Analysis Nutrition reviews 2024

PubMed DOI

B Relationship between vitamin B12 levels and motor development: A systematic review

Systematic Review Clinical nutrition ESPEN 2024

PubMed DOI

B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis

Meta Analysis Frontiers in endocrinology 2023

PubMed DOI

View all evidence for Vitamin B12 →