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St. John's Wort 450

product on market Tablet or Pill Source Naturals Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for St. John's Wort 450
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Botanical
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 300.0mg (240 products) 20 studies — no high-quality reviews

Other Ingredients

Dibasic Calcium Phosphate modified Cellulose Gum Microcrystalline Cellulose Stearic Acid Silica Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: 1 tablet twice daily. To obtain the best results, use this product for at least 6 weeks.

Warnings & Precautions

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Warning: Do not use this product while taking any medication or if you have a medical condition, without the advice of your physician or pharmacist. St. John’s wort is known to interfere with many prescription and non-prescription drugs, including oral contraceptives, antibiotics, antidepressants, anticoagulants, antihistamines, immunosuppressants, corticosteroids, diabetes drugs, antiviral, antiseizure, anticancer and cardiovascular drugs.

It may also cause increased photosensitivity; limit exposure to UV radiation.

If you are pregnant, may become pregnant, or breastfeeding, consult your healthcare professional before using this product.

Formulation Notes

Standardized to 0.3% hypericins

Source Naturals St. John's Wort 450 is standardized to consistently supply 0.3% hypericins.

Suitable for Vegetarians.

Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no sugar, starch, salt, preservatives, or artificial color, flavor or fragrance.

Additional Information

Supports a positive mental outlook 450 mg

A daily intake of St. John’s wort standardized to 2.7 mg hypericins may support a positive outlook and mood. Benefits may be experienced within 4 to 6 weeks of initial use.

Note: Natural plant variations may affect tablet color.

SN1175 REV I152

Metadata

Product Details

UPC / SKU0 21078 01175 0
DSLD Entry Date2017-08-22
Product TypeBotanical
FormTablet or Pill
DSLD ID77503
Data Updated2026-04-11
Research

Research Evidence

43
Research Sources
48
Avg Quality
16
Meta Analysis
14
Systematic Review
7
Rct
4
Regulatory Source
1
Clinical Trial
1
Openfda Safety
B St John's wort for major depression
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
B Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis
Meta Analysis Journal of affective disorders 2017 PubMed DOI
B A systematic review of St. John's wort for major depressive disorder
Meta Analysis Systematic reviews 2016 PubMed DOI
B St John's wort for depression
Systematic Review The Cochrane database of systematic reviews 2000 PubMed
B Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Meta Analysis Neuropsychopharmacology reports 2025 PubMed DOI
B St John's wort for depression
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
C St John's wort for depression: meta-analysis of randomised controlled trials
Meta Analysis The British journal of psychiatry : the journal of mental science 2005 PubMed
C The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Rct Complementary therapies in medicine 2019 PubMed DOI
C Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks
Rct BMJ (Clinical research ed.) 1999 PubMed
C Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis
Meta Analysis Scientific reports 2016 PubMed DOI
View all evidence for St Johns Wort →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.