5-Methyl Folate 5,000 mcg
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- Folate: 8333mg is 8333.0× the Tolerable Upper Intake Level (1.0mg)
- 100% of ingredients have research evidence
What the Evidence Says
AI-generated · Qwen 3.6 · grounded in 1 source · methodologyFolate is essential for DNA synthesis and cellular function, with strong evidence supporting its role in supporting healthy homocysteine levels. However, the high dosage in this product may lead to safety concerns or adverse effects in some individuals. Evidence coverage for this specific formulation remains very limited.
AI-generated summary based on research evidence. Not medical advice.
Safety Alerts
Folate: 8333mg is 8333.0× the Tolerable Upper Intake Level (1.0mg)
This product received a low safety score because it contains an amount of folate that significantly exceeds the recommended tolerable upper intake level.
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Label Data
Supplement Facts — Evidence Check
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Product Information
Directions for Use
Suggested Usage: Take 1 capsule daily with a meal, or as directed by your healthcare practitioner.
Warnings & Precautions
Cautions/Interactions: For adults only.
The elderly and individuals with conditions that may impair vitamin B-12 absorption should frequently check vitamin B-12 status when taking this product as high-dose folic acid may mask vitamin B-12 deficiency. Consult physician if pregnant/nursing, taking medication (especially phenobarbital, phenytoin, primidone, and methotrexate), or have a medical condition (especially any condition involving nutrient malabsorption).
Keep out of reach of children.
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Formulation Notes
This product utilizes a patented form of 5-MTHF with superior bioavailability.
~ Metabolically Active Folate
Quatrefolic
Vegetarian/Vegan
Non-GMO
Not manufactured with wheat, gluten, soy, milk, egg, fish shellfish or tree nut ingredients.
Additional Information
How It Works: Folate consumed in the diet or from supplements must be converted to its active form, 5-Methyltetrahydrofolate (5-MTHF), to be used by the body. This is a multi-step biochemical process that, in some circumstances, may not be efficient enough to meet the body's needs. In addition, unlike folic acid, 5-MTHF can penetrate the blood-brain barrier.
Natural color variation may occur in this product.
CODE P0492 V1
~ Superior bioavailability
Non-GMO
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Research Evidence
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.