St. John's Wort Extract 300 mg

product on market Capsule GNC Herbal Plus 🟢 Safety: 100/100
Brand: GNC Herbal Plus
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

Label for St. John's Wort Extract 300 mg
📄 Open Full PDF View on NIH DSLD →
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Label Data

1 Capsule(s) Serving Size
Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

300 mg
📊 Market median: 300.0mg (240 products) 📚 11 studies — no high-quality reviews
This product: 300mg

Other Ingredients

Cellulose Vegetable Cellulose Capsule

Label Claims — Verification

❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (78% of products) Nutrient (2% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, take one to three capsules daily.

⚠️ Warnings & Precautions

Keep out of reach of children.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery. Use of this product may cause your skin to be extra sensitive to UV sources such as artificial or natural sunlight. Avoid excessive exposures from these sources.

Potency verified by GNC procedure #5286. Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

🧪 Formulation Notes

No sugar, no artificial colors, no artificial flavors, sodium free, no wheat, gluten free, no soy, no dairy, yeast free.

Vegetarian

Additional Information

Store in a cool, dry place.

Promotes positive mood balance

Standardized extract

CODE 194522 CRG

Product Details

UPC / SKU 0 48107 12737 4
DSLD Entry Date 2017-06-23
Product Type Botanical
Form Capsule
Brand GNC Herbal Plus
DSLD ID 74615
Data Updated 2026-04-11

Research Evidence

43 Research Sources
48 Avg Quality Score
16 Meta Analysis
14 Systematic Review
7 Rct
4 Regulatory Source
1 Clinical Trial
1 Openfda Safety
B St John's wort for major depression
Systematic Review The Cochrane database of systematic reviews 2008
PubMed DOI
B Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis
Meta Analysis Journal of affective disorders 2017
PubMed DOI
B A systematic review of St. John's wort for major depressive disorder
Meta Analysis Systematic reviews 2016
PubMed DOI
B St John's wort for depression
Systematic Review The Cochrane database of systematic reviews 2000
PubMed
B Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Meta Analysis Neuropsychopharmacology reports 2025
PubMed DOI
B St John's wort for depression
Meta Analysis The Cochrane database of systematic reviews 2005
PubMed
C St John's wort for depression: meta-analysis of randomised controlled trials
Meta Analysis The British journal of psychiatry : the journal of mental science 2005
PubMed
C The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Rct Complementary therapies in medicine 2019
PubMed DOI
C Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks
Rct BMJ (Clinical research ed.) 1999
PubMed
C Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis
Meta Analysis Scientific reports 2016
PubMed DOI
View all evidence for St Johns Wort →

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St Johns Wort research & evidence Best St Johns Wort rankings All St Johns Wort products More from GNC Herbal Plus View on NIH DSLD →