🟢 87/100

This product is generally safe

  • Niacin: 400mg is 11.4× the Tolerable Upper Intake Level (35mg)
  • 67% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 400mg is 11.4× the Tolerable Upper Intake Level (35mg)

Label Data

1 Caplet(s) Serving Size
Other Combinations Product Type
67% Evidence Coverage

Supplement Facts — Evidence Check

Total Carbohydrates
1 Gram(s) (1% DV)
400 mg (2000% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 11.4× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 400mg UL 35mg
100 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 100mg

Other Ingredients

Microcrystalline Cellulose Dicalcium Phosphate Hydroxypropyl Cellulose Croscarmellose Sodium Hypromellose Stearic Acid Acacia Silicon Dioxide Magnesium Stearate Ethylcellulose Shellac Wax Triacetin Acetylated Monoglycerides Polyethylene Glycol Oleic Acid

Label Claims — Verification

All Other
Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Directions: Adults, take one (1) caplet once daily with food.

⚠️ Warnings & Precautions

Caution: Do not use this product if you are pregnant or nursing a baby. Ask a doctor before using this product if you are taking any medication, planning any medical procedure or have any medical condition including but not limited to: a known sensitivity to niacin, diabetes, heart problems, peptic ulcer disease, gall bladder disease, blood pressure problems, liver or kidney disease, gout or bleeding problems.

Discontinue use and consult a doctor if any adverse reactions occur.

Notice: Most people should not experience flushing when using this product. However, a few sensitive individuals may experience some flushing. Do not take on an empty stomach.

Keep out of the reach of children.

🧪 Formulation Notes

Inositol Hexanicotinate 500 mg

No artificial colors, artificial flavors, preservatives, wheat, gluten, milk or milk derivatives, yeast, lactose, sugar.

Gluten free

Additional Information

Helps support energy metabolism and nervous system health

094 02 1392 : 8X372 UW F1

Niacin is part of the B vitamin group and is essential for life. Niacin helps maintain the health of the nervous system and supports energy metabolism.

Store in a dry place at room temperature (59(0)F-86(0)F).

Actual size

ID692477

Product Details

UPC / SKU 0 70030 62481 1
DSLD Entry Date 2017-05-24
Product Type Other Combinations
Form Other (e.g. tea bag)
Brand up&up
DSLD ID 74314
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
View all evidence for Niacin →

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