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Niacin Flush Free

product on market Other (e.g. tea bag) up&up Safety: 87/100
87/100

This product is generally safe

  • Niacin: 400mg is 11.4× the Tolerable Upper Intake Level (35mg)
  • 67% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Niacin is supported by strong evidence for managing lipid levels, while inositol is often used to support metabolic health. Research on these ingredients is generally well-established, though the overall evidence coverage for this specific formulation is limited. The profile maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 400mg is 11.4× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Niacin Flush Free
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Caplet(s)
Serving Size
Other Combinations
Product Type
67%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Total Carbohydrates
1 Gram(s) (1% DV)
400 mg (2000% DV)
Exceeds UL by 11.4× (UL: 35 mg) 196 studies (A:5, B:63)
100 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)

Other Ingredients

Microcrystalline Cellulose Dicalcium Phosphate Hydroxypropyl Cellulose Croscarmellose Sodium Hypromellose Stearic Acid Acacia Silicon Dioxide Magnesium Stearate Ethylcellulose Shellac Wax Triacetin Acetylated Monoglycerides Polyethylene Glycol Oleic Acid
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Adults, take one (1) caplet once daily with food.

Warnings & Precautions

Caution: Do not use this product if you are pregnant or nursing a baby. Ask a doctor before using this product if you are taking any medication, planning any medical procedure or have any medical condition including but not limited to: a known sensitivity to niacin, diabetes, heart problems, peptic ulcer disease, gall bladder disease, blood pressure problems, liver or kidney disease, gout or bleeding problems.

Discontinue use and consult a doctor if any adverse reactions occur.

Notice: Most people should not experience flushing when using this product. However, a few sensitive individuals may experience some flushing. Do not take on an empty stomach.

Keep out of the reach of children.

Formulation Notes

Inositol Hexanicotinate 500 mg

No artificial colors, artificial flavors, preservatives, wheat, gluten, milk or milk derivatives, yeast, lactose, sugar.

Gluten free

Additional Information

Helps support energy metabolism and nervous system health

094 02 1392 : 8X372 UW F1

Niacin is part of the B vitamin group and is essential for life. Niacin helps maintain the health of the nervous system and supports energy metabolism.

Store in a dry place at room temperature (59(0)F-86(0)F).

Actual size

ID692477

Metadata

Product Details

UPC / SKU0 70030 62481 1
DSLD Entry Date2017-05-24
Product TypeOther Combinations
FormOther (e.g. tea bag)
Brandup&up
DSLD ID74314
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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Niacin research Best Niacin All Niacin products More from up&up View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.