Glucosamine Chondroitin MSM by Signature Care — Ingredients, Evidence & Safety

Product Label

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Label Data

2 Caplet(s) Serving Size

60 Servings

Other Combinations Product Type

38% Evidence Coverage

Supplement Facts — Evidence Check

Calories

10 Calorie(s)

Total Carbohydrates

2 Gram(s) (1% DV)

Vitamin C

60 mg (100% DV)

Manganese

2 mg (100% DV)

✅ Within RDA (0.9× RDA of 2.3 mg) 📚 8 studies — no high-quality reviews

RDA 2.3mg This product: 2mg UL 11mg

Sodium

40 mg (2% DV)

Glucosamine HCl

1500 mg

📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)

This product: 1500mg

Boswellia serrata extract

100 mg

📊 Market median: 375.0mg (171 products) 📚 30 studies (Tier A: 1, B: 14)

This product: 100mg

Chondroitin/MSM Complex

1103 mg

📊 Market median: 600.0mg (79 products) 📚 24 studies (Tier A: 0, B: 6)

This product: 1103mg

Other Ingredients

Glucosamine Hydrochloride Chondroitin Sulfate Methylsulfonylmethane Collagen Boswellia serrata Cellulose Boswellia serrata extract Crospovidone Cellulose Coating Ascorbic Acid Magnesium Stearate Bororganic Glycine Titanium Dioxide color Silica Maltodextrin Triacetin Polysorbate 80 Manganese Sulfate Sodium Hyaluronate natural Caramel color natural Palm leaf glaze

Label Claims — Verification

❓ All Other

All Other (100% of products) Structure/Function (89% of products) Nutrient (16% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Suggested Use: Take two (2) caplets daily, preferably with a meal or as directed by a healthcare practitioner.

⚠️ Warnings & Precautions

Contains shellfish (crab, crayfish, lobster, shrimp) ingredients.

Warning: If you are pregnant, nursing, taking any medications, including blood thinners, or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18.

Do not use if inner seal is broken or missing.

Keep out of the reach of children.

🧪 Formulation Notes

Contains shellfish (crab, crayfish, lobster, shrimp) ingredients.

Additional Information

Prod. No. 18636 B67216 03C

RD 16305

Quality guaranteed

Actual size

Store at room temperature, tightly closed.

Our promise Quality & satisfaction 100% guaranteed or your money back.

Product Details

UPC / SKU 0 21130 78753 1

DSLD Entry Date 2017-04-25

Product Type Other Combinations

Form Other (e.g. tea bag)

Brand Signature Care

DSLD ID 73012

Data Updated 2026-04-11

Research Evidence

39 Research Sources

50 Avg Quality Score

20 Rct

9 Meta Analysis

4 Clinical Trial

3 Systematic Review

1 Regulatory Source

1 Openfda Safety

B Interventions for the management of temporomandibular joint osteoarthritis

Systematic Review The Cochrane database of systematic reviews 2012

PubMed DOI Cochrane

B Glucosamine therapy for treating osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2005

PubMed Cochrane

B Chondroitin for osteoarthritis

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI Cochrane

B Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis

Meta Analysis Archives of orthopaedic and trauma surgery 2023

PubMed DOI

B Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis

Rct The New England journal of medicine 2006

PubMed

B Oral Glucosamine in the Treatment of Temporomandibular Joint Osteoarthritis: A Systematic Review

Systematic Review International journal of molecular sciences 2023

PubMed DOI

B Scientific Opinion on glucosamine and joint health

Regulatory Source EFSA Journal 2009

DOI

B Clinical Efficacy and Safety of Chondroitin Combined with Glucosamine in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Meta Analysis Computational and mathematical methods in medicine 2022

PubMed DOI

B Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib

Rct Annals of the rheumatic diseases 2016

PubMed DOI

B Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials

Meta Analysis Journal of orthopaedic surgery and research 2018

PubMed DOI

View all evidence for Glucosamine →