🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 33% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

2 Caplet(s) Serving Size
90 Servings
Non-Nutrient/Non-Botanical Product Type
33% Evidence Coverage

Supplement Facts — Evidence Check

1400 mg
📊 Market median: 5.0mg (298 products) 📚 701 studies (Tier A: 5, B: 123)
This product: 1400mg
CarnoSyn
200 mg
📊 Market median: 300.0mg (68 products)
Median 300.0mg This product: 200mg

Other Ingredients

Microcrystalline Cellulose Stearic Acid Magnesium Stearate Silicon Dioxide Croscarmellose Sodium coating

Label Claims — Verification

All Other
Structure/Function
All Other (98% of products) Structure/Function (93% of products) Nutrient (20% of products)

Target Groups

Women (not pregnant or lactating) Adult Male (18-50 Years)

Product Information

📋 Directions for Use

DIRECTIONS: Take 2 caplets in the morning and 2 caplets in the afternoon.

NOTE: To maximize results, drink at least 64 ounces of water daily while using CE2 HI-DEF.

ON TRAINING DAYS: Take one of your daily doses (2 caplets) 30-60 minutes before your workout to promote the utilization of fat for energy.

PRODUCT IS BEST IF USED WITHIN 45 DAYS OF BEING OPENED.

⚠️ Warnings & Precautions

KEEP OUT OF THE REACH OF CHILDREN.

Consult your physician if you are taking any over-the-counter or prescription medication. Do not use if you have been prescribed and are taking Disulfiram (Antabuse), or if you have a known hypersensitivity to any of the components in creatine or ethyl alcohol.

Not intended for use by individuals under the age of 18 years.

WARNING: Do not use if you are pregnant, nursing, at risk for or suffer from renal (kidney) or hepatic (liver) dysfunction.

Additional Information

PROTECT FROM LIGHT AND MOISTURE.

STORE AT 59-86°F (15-30°C).

* PRELIMINARY LABORATORY RESEARCH INDICATES THAT THE RASPBERRY KETONE FOUND IN CE2 HI-DEF HELPS LIPOLYSIS, FAT-MOBILIZATION, AND BETA-OXIDATION.

1 ESTER CREATINE Gain Instant Strength It all starts with University-Developed rapid-diffusion ester creatine in CE2 HI-DEF. You rapidly get the powerful strength-enhancing properties of creatine. Best of all, users report no water retention (edema), dehydration, or cramping.^

2 BETA-ALANINE Stronger - Longer! Now you can maintain your maximum strength for longer periods of time. MRI's premium beta-alanine (BA) releases carnosine, stabilizing muscle tissue "pH," giving the muscle cell the ability to flush out muscle-disabling toxins - fast. What's more, MRI's BA super-charges creatine's effect in the muscle cell, which may give you even greater performance.^

3 THERMO-RK Burn Fat - Maintain Muscle At last, you may be able to burn fat and maintain your muscle. MRI's Thermo-RK activates norepinephrine, increasing the breakdown of fat and making it available for your body to burn as muscle fuel. This also spares your glycogen stores and lean tissue. Now you can finally see yourself stronger, larger...and in HI-DEF!^

CarnoSyn(TM) Carnitine Synthesizer

ESTER - TECH Rapid Diffusion Technology

POWERED BY: Thermo-RK

CE2 HI-DEF: New "Triple Action" Complex

Enhanced with Beta-alanine^

Helps Break Down, Mobilize, and Burn Fat*^

Increases Strength in Fast Twitch (type II) and Slow Twitch (type I) Muscle Fibers^

PATENT PENDING

PICTURE YOURSELF STRONGER, LARGER, AND IN "HI-DEF!"

Prolongs Time of Maximum Strength^

RAPID ABSORPTION ESTER CREATINE

Rev. 030609

THERMOGENIC CREATINE COMPLEX

Users Report No Edema or Muscle Cramping^

You train hard. Your goal is clear. Size, Symmetry, and "Cuts." You can picture the end result: Broad muscular shoulders, a super tight waist, and highly defined muscles. And now you've got the nutraceutical technology to get you the sought-after X-frame you want, fast: CE2 HI-DEF(R)! The world's first strength-enhancing, power-prolonging, thermogenic creatine complex.^

Product Details

DSLD Entry Date 2012-03-23
Product Type Non-Nutrient/Non-Botanical
Form Other (e.g. tea bag)
Brand MRI
DSLD ID 6634
Data Updated 2026-04-11

Research Evidence

739 Research Sources
47 Avg Quality Score
472 Clinical Trial
139 Meta Analysis
74 Systematic Review
47 Rct
2 Regulatory Source
1 Cochrane Review
1 Guideline
1 Openfda Safety
A Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level: A Mega-analysis of Individual Participant-Level Data
Meta Analysis JAMA psychiatry 2021
A HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis
Meta Analysis The Cochrane database of systematic reviews 2014
A Cordyceps sinensis (a traditional Chinese medicine) for treating chronic kidney disease
Meta Analysis The Cochrane database of systematic reviews 2014
B Greater Choline-Containing Compounds and Myo-inositol in Treatment-Resistant Versus Responsive Schizophrenia: A 1H-Magnetic Resonance Spectroscopy Meta-analysis
Meta Analysis Biological psychiatry. Cognitive neuroscience and neuroimaging 2024
B Comparison of statins for secondary prevention in patients with ischemic stroke or transient ischemic attack: a systematic review and network meta-analysis
Systematic Review BMC medicine 2019
B Efficacy of Creatine Supplementation Combined with Resistance Training on Muscle Strength and Muscle Mass in Older Females: A Systematic Review and Meta-Analysis
Meta Analysis Nutrients 2021
B The Effects of Creatine Supplementation on Upper- and Lower-Body Strength and Power: A Systematic Review and Meta-Analysis
Meta Analysis Nutrients 2025
B Meta-analysis of the efficacy and safety of Finerenone in diabetic kidney disease
Meta Analysis Medicine 2026
B Creatine and creatine analogues in hypertension and cardiovascular disease
Meta Analysis The Cochrane database of systematic reviews 2011
B HMG CoA reductase inhibitors (statins) for dialysis patients
Meta Analysis The Cochrane database of systematic reviews 2013
View all evidence for Creatine →

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