Advanced Collagen by Nature's Bounty Optimal Solutions — Ingredients, Evidence & Safety

Product Label

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Label Data

3 Tablet(s) Serving Size

30 Servings

Other Combinations Product Type

33% Evidence Coverage

Supplement Facts — Evidence Check

Calories

10 Calorie(s)

Total Carbohydrates

1 Gram(s) (1% DV)

Protein

1 Gram(s) (2% DV)

Vitamin C

90 mg (150% DV)

Biotin

450 mcg (150% DV)

📊 15.0× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.45mg

Calcium

156 mg (16% DV)

Copper

3 mg (150% DV)

📊 3.3× RDA — above typical dose (UL: 10 mg) 📚 36 studies (Tier A: 0, B: 11)

RDA 0.9mg This product: 3mg UL 10mg

Sodium

15 mg (1% DV)

Hydrolyzed Collagen

1500 mg

📊 Market median: 20.0mg (931 products) 📚 233 studies (Tier A: 1, B: 90)

This product: 1500mg

Other Ingredients

Vegetable Cellulose Dicalcium Phosphate Contains <2% of:

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (95% of products) Nutrient (80% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

DIRECTIONS: For adults, take three (3) tablets daily on an empty stomach.

⚠️ Warnings & Precautions

WARNING: Not intended for use by pregnant or nursing women. If you are taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

🧪 Formulation Notes

Vitamin C, Copper & Biotin

No Artificial Flavor or Sweetener, No Preservatives, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish.

Additional Information

Vital Nutrients to Support Natural Beauty*

Vitamin C, Copper and Biotin support your natural beauty from within.* Collagen is a substance rich in amino acids, which the body needs to maintain overall health.* Copper, an essential trace mineral, plays a significant role in the synthesis of collagen.* Vitamin C helps support natural collagen production in the body for healthy skin, while biotin helps maintain healthy nails and hair.*

SA 4599 00A B52556

Prod. No. 4599 SA 4599 00A B52556 Part No. 22-04601

Store at room temperature.

Guaranteed Quality Laboratory Tested

Beauty Formula

Healthy Aging

Vital Nutrients to Support Natural Beauty*

Product Details

UPC / SKU 0 74312 04599 8

DSLD Entry Date 2016-09-22

Product Type Other Combinations

Form Tablet or Pill

Brand Nature's Bounty Optimal Solutions

DSLD ID 65024

Data Updated 2026-04-11

Research Evidence

281 Research Sources

54 Avg Quality Score

141 Meta Analysis

72 Systematic Review

45 Rct

18 Clinical Trial

2 Narrative Review

1 Other

1 Guideline

1 Openfda Safety

A Vascular closure devices for femoral arterial puncture site haemostasis

Meta Analysis The Cochrane database of systematic reviews 2016

PubMed DOI

B Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis

Meta Analysis Nutrients 2023

PubMed DOI

B Transepithelial versus epithelium-off corneal crosslinking for progressive keratoconus

Meta Analysis The Cochrane database of systematic reviews 2021

PubMed DOI

B Bisphosphonate therapy for osteogenesis imperfecta

Meta Analysis The Cochrane database of systematic reviews 2014

PubMed DOI

B Punctal occlusion for dry eye syndrome

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI

B Dressings and topical agents containing hyaluronic acid for chronic wound healing

Systematic Review The Cochrane database of systematic reviews 2023

PubMed DOI

B Efficacy of statins for osteoporosis: a systematic review and meta-analysis

Meta Analysis Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2017

PubMed DOI

B Drugs to reduce bleeding and transfusion in major open vascular or endovascular surgery: a systematic review and network meta-analysis

Systematic Review The Cochrane database of systematic reviews 2023

PubMed DOI

B Bisphosphonate therapy for osteogenesis imperfecta

Meta Analysis The Cochrane database of systematic reviews 2008

PubMed DOI

B Bisphosphonates for osteoporosis in primary biliary cirrhosis

Meta Analysis The Cochrane database of systematic reviews 2011

PubMed DOI

View all evidence for Collagen →