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Niacin

product on market Capsule Signature Care Safety: 80/100
80/100

This product is generally safe

  • Niacin: 400mg is 11.4× the Tolerable Upper Intake Level (35mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Niacin is used to support cholesterol levels and skin health, while inositol is associated with insulin sensitivity and metabolic function. There is strong evidence for niacin's efficacy, though evidence for inositol varies by condition. The overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 400mg is 11.4× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Niacin
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

400 mg (2000% DV)
Exceeds UL by 11.4× (UL: 35 mg) 196 studies (A:5, B:63)
100 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)

Other Ingredients

Inositol Hexanicotinate Gelatin Stearic Acid Contains <2% of:
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

SUGGESTED USE: Take one (1) capsule daily, preferably with a meal or as directed by a healthcare practitioner.

Warnings & Precautions

WARNING: Not intended for use by pregnant or nursing women. If you are taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

NOTICE: Most people should not experience flushing when using this product. However, a few sensitive individuals may experience a temporary skin flushing (hot feeling and skin redness), burning, itching, or rash caused by an increase in blood flow near the skin.

Do not take on an empty stomach. Do not take more than the recommended dose unless prescribed by the doctor.

DO NOT USE IF INNER SEAL IS BROKEN OR MISSING.

KEEP OUT OF REACH OF CHILDREN.

Formulation Notes

Flush Free Inositol Hexanicotinate

Additional Information

Prod. No. 65742 B1660 00A RD 16021

Quality Guaranteed

ACTUAL SIZE

OUR PROMISE QUALITY & SATISFACTION 100% GUARANTEED OR YOUR MONEY BACK.

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Metadata

Product Details

UPC / SKU0 21130 79897 1
DSLD Entry Date2016-09-22
Product TypeOther Combinations
FormCapsule
BrandSignature Care
DSLD ID63153
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.