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SAM-e 400 mg

product on market Tablet or Pill Nature's Bounty Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for SAM-e 400 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Non-Nutrient/Non-Botanical
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 500.0mg (193 products) 7 studies — no high-quality reviews

Other Ingredients

Vegetable Cellulose Polymethacrylate Contains <2% of:
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS: For adults, take one (1) tablet three times daily, preferably on an empty stomach. In order to obtain maximum benefits, SAM-e should be taken at least 30 minutes prior to a meal.

Warnings & Precautions

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if blister seal is cut, torn or open.

Formulation Notes

Non-GMO, No Artificial Flavor, No Preservatives, No Sugar, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish.

Additional Information

Our enteric coating helps the breakdown of SAM-e occur in the small intestine.* In addition, the enteric coating is designed to protect SAM-e from moisture and serve as a protective barrier so that SAM-e can be absorbed where it can provide you with the greatest benefits.*

Store at room temperature.

Made In The USA with select ingredients from around the world

Over 40 years of trusted quality At Nature’s Bounty, we are committed to your health. For over 40 years we have been making trusted products, backed by science, and made with only the purest ingredients...guaranteed. So you can get the most out of life every day.

Enteric Coated Tablets and Stomach Friendly Guaranteed Quality Laboratory Tested

Nutrition Questions or Comments? Call 1-800-433-2990 Mon. - Sat. 9 AM - 7 PM ET Join our Loyalty Program at NaturesBountyRewards.com

Prod. No. 13185 07F B36222

Good for Joint Health Supports Emotional Well-Being

The body makes SAM-e from the amino acid methionine. However, you may not be able to obtain sufficient methionine levels simply by ingesting food. In addition, because of age or other factors, levels of SAM-e can fluctuate or decline. Supplementation with SAM-e is the easiest way to increase intake. This remarkable supplement can be used for: ~ Emotional Well-Being ~ Joint Health

Metadata

Product Details

UPC / SKU0 74312 13185 1
DSLD Entry Date2016-06-24
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
DSLD ID62057
Data Updated2026-04-11
Research

Research Evidence

14
Research Sources
50
Avg Quality
8
Rct
4
Meta Analysis
2
Clinical Trial
B The Effect of Fenugreek in Type 2 Diabetes and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis International journal of molecular sciences 2023 PubMed DOI
B A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes
Rct African health sciences 2019 PubMed DOI
C The effect of fenugreek seed supplementation on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus: A parallel randomized clinical trial
Rct Complementary therapies in medicine 2020 PubMed DOI
C Effect of saffron and fenugreek on lowering blood glucose: A systematic review with meta-analysis
Meta Analysis Phytotherapy research : PTR 2023 PubMed DOI
C Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis
Meta Analysis Journal of ethnopharmacology 2016 PubMed DOI
C Effect of fenugreek extract supplement on testosterone levels in male: A meta-analysis of clinical trials
Meta Analysis Phytotherapy research : PTR 2020 PubMed DOI
C Investigating the Effectiveness of Fenugreek on the Quantity of Breast Milk and the Level of Prolactin in Mothers of Preterm Newborns: A Randomized Controlled Clinical Trial
Rct Current drug research reviews 2025 PubMed DOI
C Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus
Rct Chinese journal of integrative medicine 2008 PubMed
C Impact of Fenugreek Supplementation on Obesity and Hyperglycemia Among Diabetic Adults in Saudi Arabia
Clinical Trial ClinicalTrials.gov 2025
C Fenugreek bread: a treatment for diabetes mellitus
Rct Journal of medicinal food 2009 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.