Home/ Supplements/ Fenugreek/ SAMe 200 mg S-Adenosyl-Methionine

SAMe 200 mg S-Adenosyl-Methionine

product on market Tablet or Pill Life Extension Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for SAMe 200 mg S-Adenosyl-Methionine
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Tablet(s)
Serving Size
10
Servings
Non-Nutrient/Non-Botanical
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 500.0mg (193 products) 7 studies — no high-quality reviews

Other Ingredients

Cellulose Mannitol Hydroxypropyl Methylcellulose Phthalate Citric Acid Stearic Acid Silica Glyceryl Triacetate Sodium Starch Glycolate Croscarmellose Sodium Titanium Dioxide yellow Ochre
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS: Take two (2) tablets two to three times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare practitioner. Take with co-factors vitamins B12, B6, and folic acid.

Warnings & Precautions

CAUTION: SAMe should not be taken by those diagnosed with bipolar disorder.

WARNINGS ~ KEEP OUT OF REACH OF CHILDREN.

DO NOT EXCEED RECOMMENDED DOSE. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Additional Information

Q00358D

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Store in a cool dry place.

Supports Healthy Bones, Joints, and Emotional Well-Being

Metadata

Product Details

UPC / SKU7 37870 35802 2
DSLD Entry Date2016-04-22
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
BrandLife Extension
DSLD ID58700
Data Updated2026-04-11
Research

Research Evidence

14
Research Sources
50
Avg Quality
8
Rct
4
Meta Analysis
2
Clinical Trial
B The Effect of Fenugreek in Type 2 Diabetes and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis International journal of molecular sciences 2023 PubMed DOI
B A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes
Rct African health sciences 2019 PubMed DOI
C The effect of fenugreek seed supplementation on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus: A parallel randomized clinical trial
Rct Complementary therapies in medicine 2020 PubMed DOI
C Effect of saffron and fenugreek on lowering blood glucose: A systematic review with meta-analysis
Meta Analysis Phytotherapy research : PTR 2023 PubMed DOI
C Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis
Meta Analysis Journal of ethnopharmacology 2016 PubMed DOI
C Effect of fenugreek extract supplement on testosterone levels in male: A meta-analysis of clinical trials
Meta Analysis Phytotherapy research : PTR 2020 PubMed DOI
C Investigating the Effectiveness of Fenugreek on the Quantity of Breast Milk and the Level of Prolactin in Mothers of Preterm Newborns: A Randomized Controlled Clinical Trial
Rct Current drug research reviews 2025 PubMed DOI
C Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus
Rct Chinese journal of integrative medicine 2008 PubMed
C Impact of Fenugreek Supplementation on Obesity and Hyperglycemia Among Diabetic Adults in Saudi Arabia
Clinical Trial ClinicalTrials.gov 2025
C Fenugreek bread: a treatment for diabetes mellitus
Rct Journal of medicinal food 2009 PubMed DOI
View all evidence for Fenugreek →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.