SAMe Enteric Coated 200 mg by The Vitamin Shoppe — Ingredients, Evidence & Safety

Product Label

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Label Data

1 Tablet(s) Serving Size

Non-Nutrient/Non-Botanical Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

S-Adenosyl-L-Methionine

200 mg

📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)

This product: 200mg

Other Ingredients

Cellulose Silica Magnesium Stearate Riboflavin Ethyl Cellulose Oleic Acid Medium Chain Triglycerides Sodium Alginate Modified Cellulose Triacetin Calcium Carbonate Ammonium Hydroxide

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

DIRECTIONS: As a dietary supplement, take one (1) tablet twice per day on an empty stomach, or as directed by your physician.

⚠️ Warnings & Precautions

WARNING: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

KEEP OUT OF REACH OF CHILDREN.

TAMPER EVIDENT Do not use if outer seal is broken or missing.

🧪 Formulation Notes

gluten free dairy free soy free nut free

Does not contain: Wheat, Gluten, Sugar, Soy, Dairy, Citrus, Fish, Animal Derivatives, Preservatives or Artificial Flavors.

Additional Information

specialty

mood liver

{tablet} actual size

STORE IN A COOL, DRY PLACE.

Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.

Item No. VS-1685 1299536 JP 53

Product Details

UPC / SKU 7 66536 01685 3

DSLD Entry Date 2016-02-23

Product Type Non-Nutrient/Non-Botanical

Form Tablet or Pill

Brand The Vitamin Shoppe

DSLD ID 55457

Data Updated 2026-04-11

Research Evidence

12 Research Sources

58 Avg Quality Score

8 Meta Analysis

3 Systematic Review

1 Rct

B S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2006

PubMed

B S-adenosyl methionine (SAMe) for depression in adults

Meta Analysis The Cochrane database of systematic reviews 2016

PubMed

B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease

Meta Analysis Annals of the rheumatic diseases 2024

PubMed DOI

B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis

Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024

PubMed DOI

B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis

Meta Analysis General hospital psychiatry 2024

PubMed DOI

B S-adenosyl-L-methionine for alcoholic liver diseases

Systematic Review The Cochrane database of systematic reviews 2001

PubMed

B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis