🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade

Product Label

📸

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Label Data

1 Capsule(s) Serving Size
30 Servings
Botanical Product Type
0% Evidence Coverage

Supplement Facts — Evidence Check

600 mg
📊 Market median: 450.0mg (130 products) 📚 1 studies — no high-quality reviews
This product: 600mg

Other Ingredients

Rice Bran powder Gelatin Capsule Magnesium Stearate

Label Claims — Verification

All Other
All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

SUGGESTED USE: Take one capsule twice daily (30 min. before meals) or as directed by your physician.

⚠️ Warnings & Precautions

KEEP OUT OF REACH OF CHILDREN.

Do not use if pregnant or nursing. Stop use if adverse reactions develop.

🧪 Formulation Notes

Standardized to contain a minimum of 0.5% pentacyclic oxindole alkaloids (POAs).

Guaranteed to be 100% free of tetracyclic oxindole alkaloids (TOAs).

Sugar Free - Sodium Free - Gluten Free - Dairy Free

Additional Information

STORAGE: Keep tightly closed at room temperature. (59-86F or 15-30C)

600 mg

Made in the USA

(fish symbol)

TOA Free POA 0.5% Guaranteed

Product Details

UPC / SKU 7 28650 00121 4
DSLD Entry Date 2011-12-23
Product Type Botanical
Form Capsule
Brand NutraMedix
DSLD ID 4096
Data Updated 2026-04-11

Research Evidence

12 Research Sources
58 Avg Quality Score
8 Meta Analysis
3 Systematic Review
1 Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024
View all evidence for Same →

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