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Homocysteine Blocker

product on market Tablet or Pill The Vitamin Shoppe Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 75% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Vitamin B6, B12, folic acid, and trimethylglycine are utilized to support the metabolism of homocysteine. There is strong evidence that these B vitamins and amino acids help lower elevated homocysteine levels in the blood. This combination targets biochemical pathways essential for cardiovascular and neurological health.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Homocysteine Blocker
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Other Combinations
Product Type
75%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

25 mg (1250% DV)
19.2× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
400 mcg (100% DV)
Within RDA (1.0× RDA) 226 studies (A:10, B:105)
250 mcg (4167% DV)
104.2× RDA — above typical dose 139 studies (A:1, B:44)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Dicalcium Phosphate Microcrystalline Cellulose Stearic Acid Magnesium Stearate purified Water Hydroxypropyl Methylcellulose Polyethylene Glycol
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

DIRECTIONS: As a dietary supplement, take one (1) to three (3) tablets daily, preferably with meals.

Warnings & Precautions

TAMPER EVIDENT Do not use if outer seal is broken or missing.

WARNING: Consult your healthcare provider prior to use if you have a renal disorder, are pregnant, nursing, taking any medication or have any medical conditions.

KEEP OUT OF REACH OF CHILDREN.

Formulation Notes

gluten free dairy free soy free nut free

Does not contain: Yeast, Corn, Wheat, Gluten, Salt, Soy, Dairy, Fish, Preservatives, Artificial Colors or Flavors.

Additional Information

Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.

{QRC} learn more at vsquality.net

Item No. VS-1776 1545854 BO 1

STORE IN A COOL, DRY PLACE.

specialty

cardiovascular

{tablet} actual size

Metadata

Product Details

UPC / SKU7 66536 01776 8
DSLD Entry Date2014-08-26
Product TypeOther Combinations
FormTablet or Pill
BrandThe Vitamin Shoppe
DSLD ID35990
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.