🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Label Data

1 Capsule(s) Serving Size
30 Servings
Non-Nutrient/Non-Botanical Product Type
100% Evidence Coverage

Supplement Facts — Evidence Check

📊 Market median: 200.0mg (52 products) 📚 10 studies (Tier A: 0, B: 6)
This product: 200mg

Other Ingredients

Hypromellose Gellan Gum Water Ascorbyl Palmitate Calcium Oxide Silica Calcium Chloride Anhydrous

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (83% of products) Nutrient (6% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Take one capsule daily, or as directed by your healthcare professional.

⚠️ Warnings & Precautions

Consult your healthcare professional prior to use. Use special caution in individuals with bipolar disorder. Do not use if foil is punctured.

Individuals taking medication should discuss potential interactions with their healthcare professional.

Storage: Keep closed in a cool, dry place out of reach of children.

🧪 Formulation Notes

THE Methyl Donor

XYMOGEN Exclusive Professional Formulas

SAMe (S-adenosyl-L-methionine) is a molecule that is naturally formed in the body. SAMe is a methyl donor in a process essential to normal cell health and function known as methylation. The methylation process can decline with age or as a result of chronic alcohol consumption, and it can be limited by genetic defects. SAMe contributes to the synthesis, activation, and metabolism of neurotransmitters, proteins, nucleic acids, phospholipids, hormones, and some drugs. It supports glutathione production, liver health, joint comfort, and a healthy mood.

Gnosis' Adomix contains a minimum of 70% of the SS isomer of SAMe, the form the body can use most readily. This relatively high concentration makes SAM-e cost-effective. Each capsule is sealed in a nitrogen-purged blister pack to maximize protection from the environment.

Formulated to exclude: Wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.

Vegetarian Caps

Additional Information

New Packaging!

ePV (ePedigree Verification)

Storage: Keep closed in a cool, dry place out of reach of children.

GMP Compliant Third-Party Verified

Scan to learn more!

Product Details

UPC / SKU 8 71149 00027 1
DSLD Entry Date 2025-09-25
Product Type Non-Nutrient/Non-Botanical
Form Capsule
Brand XYMOGEN
DSLD ID 335564
Data Updated 2026-04-11

Research Evidence

12 Research Sources
58 Avg Quality Score
8 Meta Analysis
3 Systematic Review
1 Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024
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