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St. John's Wort

product on market Capsule Cyto-Matrix Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • Limited research evidence available for ingredients
B Label Compliance Grade
Label

Product Label

Label for St. John's Wort
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
90
Servings
Botanical
Product Type
0%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 300.0mg (240 products) 20 studies — no high-quality reviews

Other Ingredients

Brown Rice, Powder Hypromellose Magnesium Stearate Microcrystalline Cellulose
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions Adults (18 years and older) - Take 1 capsule, 2 times per day. Use for at least 1 week to see beneficial effects. Consult a healthcare professional for use beyond 18 weeks.

Warnings & Precautions

Warnings Do not use this product if you are taking anti-cancer medications, antidepressant [e.g. selective serotonin reuptake inhibitors (SSRI)], cardiovascular medications, contraceptive medications, blood thinners, anti-HIV agents, medications to suppress the immune system (immunosuppressive medications). Consult a healthcare professional prior to use if you are pregnant, you are breastfeeding, you are taking antianxiety medications, you are taking seizure medications, you are taking antihistamines, you are taking bronchodilators, you are taking muscle relaxants, you are taking opiates.

Avoid prolonged exposure to sunlight, ultraviolet light (UV), UV therapy. Consult a healthcare professional if symptoms persist or worsen. Some people may experience mild gastrointestinal disturbances, nausea, restlessness and headaches.

Keep out of reach of children.

Other information Do not use if safety seal is broken.

Stop use if hypersensitivity/allergy occurs.

Formulation Notes

Professional Naturopathic Formulations Made in Canada

Uses Helps promote healthy mood balance and relieve sleep disturbances associated with mood imbalance. Traditionally used in Herbal Medicine to help relieve restlessness and nervousness.

Vegan.

GMO, gluten, soy and dairy free.

Additional Information

NPN 80114463

Peel for more information

Questions? Reach us at info@cytomatrix.co Cytomatrix.ca

Metadata

Product Details

UPC / SKU8 71740 00164 6
DSLD Entry Date2025-09-25
Product TypeBotanical
FormCapsule
DSLD ID334487
Data Updated2026-04-11
Research

Research Evidence

43
Research Sources
48
Avg Quality
16
Meta Analysis
14
Systematic Review
7
Rct
4
Regulatory Source
1
Clinical Trial
1
Openfda Safety
B St John's wort for major depression
Systematic Review The Cochrane database of systematic reviews 2008 PubMed DOI
B Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis
Meta Analysis Journal of affective disorders 2017 PubMed DOI
B A systematic review of St. John's wort for major depressive disorder
Meta Analysis Systematic reviews 2016 PubMed DOI
B St John's wort for depression
Systematic Review The Cochrane database of systematic reviews 2000 PubMed
B Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis
Meta Analysis Neuropsychopharmacology reports 2025 PubMed DOI
B St John's wort for depression
Meta Analysis The Cochrane database of systematic reviews 2005 PubMed
C St John's wort for depression: meta-analysis of randomised controlled trials
Meta Analysis The British journal of psychiatry : the journal of mental science 2005 PubMed
C The effect of Hypericum perforatum on postmenopausal symptoms and depression: A randomized controlled trial
Rct Complementary therapies in medicine 2019 PubMed DOI
C Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks
Rct BMJ (Clinical research ed.) 1999 PubMed
C Hypericum perforatum as a cognitive enhancer in rodents: A meta-analysis
Meta Analysis Scientific reports 2016 PubMed DOI
View all evidence for St Johns Wort →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.