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Sleep Breakthrough

product on market Capsule BiOptimizers Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 62% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Magnesium, glycine, and taurine are supported by moderate evidence for promoting relaxation and improving sleep quality. Vitamin B6 and zinc serve as essential cofactors for neurotransmitter synthesis. Overall, the evidence coverage for this specific ingredient profile is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Sleep Breakthrough
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
62%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

2.4 mg (141% DV)
1.8× RDA — within safe limits 114 studies (A:3, B:35)
36 mg (9% DV)
Within RDA (0.1× RDA) 316 studies (A:8, B:159)
1.5 mg (14% DV)
Within RDA (0.1× RDA) 263 studies (A:6, B:134)
Glycine
588 mg
190 mg
Market median: 500.0mg (180 products) 5 studies (A:0, B:1)
190 mg
Market median: 200.0mg (358 products) 9 studies (A:0, B:2)
Magnolia Bark Extract
75 mg

Other Ingredients

Hypromellose Potassium Gluconate Calcium Citrate Rice Extract Rice Husk Gum Arabic Sunflower Oil Rice Fiber Microcrystalline Cellulose
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 2 capsules one hour prior to bedtime.

Warnings & Precautions

Caution: Use only as directed. Do not use if imprinted seal under cap is broken, damaged, or missing. Discontinue use if adverse effects occur. To report a serious adverse event, or obtain product information, contact 1 (800) 719-2467 or visit BIOptimizers.com.

Keep out of reach of children.

As with any product, consult a healthcare practitioner prior to use, especially if you are pregnant or nursing, have a serious medical condition, or use any medications.

Formulation Notes

Sleep Breakthrough offers a melatonin-free option to support restful sleep, and enhance a feeling of refreshment upon wakening. This formula is designed to promote restorative sleep, support sleep quality, and promote a state of relaxation.

Sleep Breakthrough offers a melatonin-free option to support restful sleep, and enhance a feeling of refreshment upon wakening. Unlike melatonin supplements, this formula contains no hormones and is safe to take daily or only as needed.

Made in the USA with globally sourced ingredients.

Optimized sleep support Melatonin-free sleep support

Melatonin-free sleep support Gluten free Soy-free

Vegan

Additional Information

Store in a cool, dry place away from direct sunlight.

Metadata

Product Details

UPC / SKU8 50064 05115 5
DSLD Entry Date2025-08-22
Product TypeOther Combinations
FormCapsule
BrandBiOptimizers
DSLD ID334479
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.