🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 62% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

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Label Data

2 Capsule(s) Serving Size
30 Servings
Other Combinations Product Type
62% Evidence Coverage

Supplement Facts — Evidence Check

2.4 mg (141% DV)
✅ 1.8× RDA — within safe limits 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 2.4mg UL 100mg
36 mg (9% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 36mg
1.5 mg (14% DV)
✅ Within RDA (0.1× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 1.5mg UL 40mg
Glycine
588 mg
190 mg
📊 Market median: 500.0mg (180 products) 📚 5 studies (Tier A: 0, B: 1)
This product: 190mg
190 mg
📊 Market median: 200.0mg (358 products) 📚 9 studies (Tier A: 0, B: 2)
This product: 190mg
Magnolia Bark Extract
75 mg

Other Ingredients

Hypromellose Potassium Gluconate Calcium Citrate Rice Extract Rice Husk Gum Arabic Sunflower Oil Rice Fiber Microcrystalline Cellulose

Label Claims — Verification

All Other
Structure/Function
All Other (98% of products) Structure/Function (89% of products) Nutrient (43% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Take 2 capsules one hour prior to bedtime.

⚠️ Warnings & Precautions

Caution: Use only as directed. Do not use if imprinted seal under cap is broken, damaged, or missing. Discontinue use if adverse effects occur. To report a serious adverse event, or obtain product information, contact 1 (800) 719-2467 or visit BIOptimizers.com.

Keep out of reach of children.

As with any product, consult a healthcare practitioner prior to use, especially if you are pregnant or nursing, have a serious medical condition, or use any medications.

🧪 Formulation Notes

Sleep Breakthrough offers a melatonin-free option to support restful sleep, and enhance a feeling of refreshment upon wakening. This formula is designed to promote restorative sleep, support sleep quality, and promote a state of relaxation.

Sleep Breakthrough offers a melatonin-free option to support restful sleep, and enhance a feeling of refreshment upon wakening. Unlike melatonin supplements, this formula contains no hormones and is safe to take daily or only as needed.

Made in the USA with globally sourced ingredients.

Optimized sleep support Melatonin-free sleep support

Melatonin-free sleep support Gluten free Soy-free

Vegan

Additional Information

Store in a cool, dry place away from direct sunlight.

Product Details

UPC / SKU 8 50064 05115 5
DSLD Entry Date 2025-08-22
Product Type Other Combinations
Form Capsule
Brand BiOptimizers
DSLD ID 334479
Data Updated 2026-04-11

Research Evidence

153 Research Sources
55 Avg Quality Score
71 Systematic Review
51 Meta Analysis
19 Rct
6 Clinical Trial
2 Other
2 Regulatory Source
1 Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022
View all evidence for Vitamin B6 →

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