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5-HTP 100 mg Time Release

product on market Tablet or Pill Natrol Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 50% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

5-Hydroxytryptophan is used to support serotonin levels, with moderate evidence suggesting its role in managing mood and sleep. Calcium serves as a structural mineral for bone health. Overall, research coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP 100 mg Time Release
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
45
Servings
Other Combinations
Product Type
50%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calcium
32 mg (2% DV)
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Hypromellose Microcrystalline Cellulose Stearic Acid Silicon Dioxide Magnesium Stearate Methylcellulose Glycerin
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Adults, take 1 tablet, up to two times daily with a meal.

Warnings & Precautions

Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, or are taking medication or have a medical condition; including drugs for depression, migraines, Parkinson's disease or psychiatric disorders.

Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, or are taking medication or have a medical condition; including drugs for depression, migraines, Parkinson's disease or psychiatric disorders. Keep out of reach of children.

Do not use with other supplements containing L-Tryptophan or 5-HTP. If adverse reactions occur, discontinue use.

Do not exceed recommended intake.

Do not use if safety seal is damaged or missing.

Formulation Notes

Natrol 5-HTP 100 mg Time Release: Controlled release tablet releases 5-HTP slowly to help support a balanced mood and promote production of serotonin throughout the day.

Mood + Stress Helps support a balanced mood Promotes production of serotonin throughout the day

100% Drug free

No: Milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans, sesame

Additional Information

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU0 47469 05228 7
DSLD Entry Date2025-06-25
Product TypeOther Combinations
FormTablet or Pill
BrandNatrol
DSLD ID332249
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.